In this review I discuss the current non-surgical treatment options for Peyronie's disease (PD), which remains a therapeutic dilemma for the treating physician. This is despite a large array of treatments that have been used since the time of de la Peyronie in the mid-18th century. Part of the problem with finding an effective treatment is the incomplete understanding of the aetiopathophysiolog...

Stem cells have the ability to propagate through self renewal and generate mature cells of multiple lineages through differentiation [1,2]. Explorations of the potential value of stem cell therapy in urology have included studies of bladder dysfunction, erectile dysfunction (ED), stress urinary incontinence (SUI), and prostate and bladder cancer. Only a few pilot human translational studies stu...

Peyronie’s disease is a connective tissue disorder affecting the tunica albuginea of the penis, causing a myriad of problems including penile pain, erectile dysfunction, penile deformity, and difficulty in performing coitus. Francois de la Peyronie first described this in 1743 while he was the surgeon for Louis XIV of France. Although the exact prevalence is unknown, it is relatively common wit...

The corpus callosum (Latin: ‘tough body’) is the human brain’s largest white matter tract, and its largest commissure. The callosum was first named by Galen of Pergamum in ancient Rome, at the beginning of the first century AD, among a range of other central nervous system structures. Up until the 16th century, it was generally felt to be a supporting or ‘scaffolding’ structure only. In 1543, A...

s and presentations related to this grant (penile fibrosis and CVOD) . A9. Vernet D, Heydarkhan S, Kovanecz I, Lue Y-H, Rajfer J, Gonzalez-Cadavid NF (2009). Characterization of endogenous stem cells from the mouse penis that express an embryonic stem cell gene and undergo differentiation into several cell lineages. Am Urol Assoc Meet, Chicago, IL, J Urol,

Penile prosthesis implantation is the recommended treatment in patients with penile curvature and severe erectile dysfunction (ED) not responding to pharmacotherapy. Most patients with mild-to-moderate curvature can expect cylinder insertion to correct both ED and penile curvature. In patients with severe curvature and in those with persistent curvature after corporeal dilation and prosthesis p...

Erectile dysfunction is prevalent among men and will continue to become more so with the aging population. Of the available treatment options, implantable prosthetic devices are typically thought of as a third line treatment even though they have the highest satisfaction rate and continually improving success rates. Infection and mechanical failure are the most common reasons for implant revisi...