نتایج جستجو برای: pfam database
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Abstract Background The illicit use of anabolic androgenic steroids (AAS) has been associated with diminished cholesterol efflux mediated by HDL, remarkable decrease in high-density lipoprotein (HDL) plasma concentration and subclinical coronary artery disease (CAD). Inflammation is the key to atherogenic process atherosclerotic plaque vulnerability. pericoronary mean fat attenuation (pFAM) eme...
In this paper, the amino acid sequence of the β-xylanase SRXL1 of Sporisorium reilianum, which is a pathogenic fungus of maize was used as a model protein to find its phylogenetic relationship with other xylanases of Ascomycetes and Basidiomycetes and the information obtained allowed to establish a hypothesis of monophyly and of biological role. 84 amino acid sequences of β-xylanase obtained fr...
Abstract It has been proven that three‐dimensional protein structures could be modeled by supplementing homologous sequences with metagenome sequences. Even though a large volume of data is utilized for such purposes, significant proportion proteins remain unsolved. In this review, we focus on identifying ecological and evolutionary patterns in data, decoding the complicated relationships these...
Molina and van Nimwegen [1] recently reported scaling exponents for different functional groups of genes and analysed the distribution of these scaling coefficients across clades and lifestyles. On the basis of the overlap between the 99% confidence intervals of their fits, they conclude that, for almost all functional groups, the exponents are equal (‘universal’) for all Prokaryotes. They plac...
Kunitz type trypsin inhibitor (KTI) family is one of the most versatile families of protease inhibitors. Their exact natural physiological role in plants is still unclear. According to some reports, KTIs are involved in proper growth and development of plants. Some researchers suggested their role in recovery from physical damage, while others have shown their applications in plant’s defence fr...
Efficient determination of structural similarities between protein binding pockets is an important challenge in computational chemistry. A degree of similarity in the mutual comparison is often estimated in terms of graphs and by calculating a metric such as the maximum shared common subgraph. Cavbase [1] was developed as a tool for the automatic detection, storage and classification of putativ...
Genome3D (http://www.genome3d.eu) is a collaborative resource that provides predicted domain annotations and structural models for key sequences. Since introducing Genome3D in a previous NAR paper, we have substantially extended and improved the resource. We have annotated representatives from Pfam families to improve coverage of diverse sequences and added a fast sequence search to the website...
Background: The Mycobacterium tuberculosis complex (MTBC) bacteria include the slowly growing, host-associated tuberculosis, Bovis, microti, africanum, pinnipedii. Aim: Comparative Functional Genomics Studies for understanding Hypothetical Proteins in variant microti 12. Objective: A computational genomics study was performed to understand 247 hypothetical protein genes. annotation of virtual p...
MOTIVATION Detecting homologous proteins is one of the fundamental problems in computational biology. Many tools to solve this problem have been developed, but development of a simple, effective and generally applicable method is still desirable. RESULTS We propose a simple but effective information retrieval approach, named SIMPRO, to identify homology relationship between proteins. The key ...
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