نتایج جستجو برای: pharmacodynamics
تعداد نتایج: 10634 فیلتر نتایج به سال:
The paper deals with changes in pharmacodynamics (the study of what the drug does to the body) and pharmacokinetics (the study of what the body does to the drug) in the elderly. Elderly population takes 25–30 per cent of drugs taken by total population. In the elderly pharmacodynamics and pharmacokinetics are altered. According to pharmacokinetics, gastric juice pH is elevated which influences ...
This review focuses on pharmacokinetics and pharmacodynamics of opioid and non-opioid analgesics in neonates and infants. The unique physiology of this population differs from that of adults and impacts drug handling. Morphine and remifentanil are described as examples of older versus recently developed opiates to compare and contrast pharmacokinetics and pharmacodynamics in infants. Exploratio...
BACKGROUND Drugs are routinely combined in anesthesia and pain management to obtain an enhancement of the desired effects. However, a parallel enhancement of the undesired effects might take place as well, resulting in a limited therapeutic usefulness. Therefore, when addressing the question of optimal drug combinations, side effects must be taken into account. METHODS By extension of a previ...
OBJECTIVE To demonstrate pharmacokinetic equivalence of CT-P10 and innovator rituximab (RTX) in patients with rheumatoid arthritis (RA) with inadequate responses or intolerances to antitumour necrosis factor agents. METHODS In this randomised phase I trial, patients with active RA were randomly assigned (2:1) to receive 1000 mg CT-P10 or RTX at weeks 0 and 2 (alongside continued methotrexate ...
Results The search yielded 309 papers; 60 were selected according to the above-mentioned criteria. The main gaps identified in all retrieved papers were: limited relevance of both updated local patterns of AMR and antimicrobial pharmacokinetics and pharmacodynamics; and no integration with infection control policies to prevent transmission of multidrug-resistant organisms (MDRO). Monitoring and...
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