Part of the uncertainty is generated by the bias of those occupying the poles of thought that must be repeatedly referred to: the dominant feeling that marijuana is a frighteningly dangerous drug in no way comparable to any accepted social drug, and the often equally emotional claim by groups of increasing size that it is a purely beneficent drug in no way comparable to any acceptable social drug.

This review offers an overview of physiological agents, current therapeutics, as well as medications, which have been extensively used and those agents not currently available or non-classically considered anti-obesity drugs. As obesity - particularly that of central distribution - represents an important triggering factor for insulin resistance, its pharmacological treatment is relevant in the...

S21 Am J Health-Syst Pharm—Vol 70 May 15, 2013 Suppl 1 of anticoagulant activity. Thromb Haemost. 2010; 103:1116-27. 48. Gulseth MP, Michaud J, Nutescu EA. Rivaroxaban: an oral direct inhibitor of factor Xa. Am J Health-Syst Pharm. 2008; 65:1520-9. 49. Kubitza D, Becka M, Mueck W et al. Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, dir...

442 September 2014 A S anesthesiologists, we routinely administer drugs that compromise a patient’s ability to breathe, and dealing with the consequences can be a challenge. However, our jobs may be getting easier. In this issue, Roozekrans et al.1 present two small, human studies on male volunteers conducted in The Netherlands on a promising new breathing stimulant compound, GAL021, being deve...

This study aimed to characterize and compare the efficacy profile on six fibromyalgia syndrome (FM) core symptoms associated with pharmacologic and non-pharmacologic treatments. We screened PubMed, Embase and the Cochrane Library for FM articles from 1990 to September 2012 to analyse randomized controlled trials comparing pharmacologic or non-pharmacologic treatments to placebo or sham. Papers ...