Pridopidine is in clinical trials for Huntington’s disease treatment. Originally developed as a dopamine D2 receptor (D2R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows disease progression and improves motor function in Huntington’s disease model mice and, in preliminarily reports, Huntington’s disease patients....

Central effects of phencyclidine HC1 (Sernyl, Parke Davis & Co.) were studied in cats. Imme diately after i.v. injection, 1-2 mg/kg, the animal lost righting ability. Respiration became irregular, inspiratory spasticity being prominent. Nystagmus and mydriasis with irregular change in pupil size were noticed. Knee jerk reflex was somewhat exaggerated and tonic neck reflex was present. Although ...

Using a-tetralone, as starting material, a series of phencyclidine analogues were synthesized. This ketone was reacted separately with ethylmagnesium bromide, P-methoxyphenylmagnesium bromide and P-methylphenylmagnesium bromide. The resultant alcohols were treated with a suspension of NaN3 and CCl3COOH in CHCl3. The azides were subsequently...

"A man for all seasons" -Sir Thomas More, so described by Robert Whittington in 1520. "More is a man of an angel's wit and singular learning. And as time requireth a man of marvellous mirth and pastimes and sometimes of a sad gravity. A man for all seasons". Since David Bolt's play, these words have become somewhat hackneyed and over-plagiarized and I do offer a scant apology in their use again...