The geno- and cytotoxicity of chromate, an important environmental pollutant, is partly attributed to the flavoenzyme-catalyzed reduction with the concomitant formation of reactive oxygen species. The aim of this work was to characterize the role of NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase, EC 1.6.99.2) and glutathione reductase (GR, EC 1.6.4.2) in the mammalian cell cytotoxicity of ...

Single crystals of organic compounds are perfectly suitable for top field-effect transistors (OFETs) because their arranged atomic pressing and smooth surface. Crystals o-phenylenediamine dihydrochloride polychloride, C6H4(NH2)2·2HCl ([OPDDH]c) is magnificently synthesized in a highly acidic medium; crystal structure determined as monoclinic, space group C2/c, with = 7.324(2), b 14.497 (5), c 7...

The synthesis and characterization of a set of conjugated polymers, poly(1,4-phenylene-ethynylene)-alt-poly(1,4-phenylene-vinylene)s (PPE-PPVs), with a dissymmetrical configuration (partial or total) of alkoxy side chains is reported. Five new polymers bearing octyloxy and/or octadecyloxy side chains at the phenylene-ethynylene and phenylene-vinylene segments, respectively, were obtained. Two s...

Yamashita and Butler [I] have shown that extraction of chloroplasts with a high concentration of Tris (0.8 M, pH 8.0) eliminates flow of electrons from water to nicotinamide adenine dinucleotide phosphate (NADP+)* or other Hill oxidants. They suggest that washing with Tris causes a block on the water side of the electron transport chain. Addition of electron donors such as reduced phenylene dia...

High-throughput screening (HTS) involves testing of compound libraries against validated drug targets using quantitative bioassays to identify 'hit' molecules that modulate the activity of target, which forms the starting point of a drug discovery effort. Eicosanoids formed via cyclooxygenase (COX) and lipoxygenase (LOX) pathways are major players in various inflammatory disorders. As the conve...

In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle...

A comprehensive computational examination of alternatively plausible mechanistic pathways for the intramolecular hydroamination (HA) of aminoalkenes utilising a recently reported novel phenylene-diamine aluminium amido compound is presented. On the one hand, a proton-assisted concerted N-C/C-H bond-forming pathway to afford the cycloamine in a single step can be invoked, and, on the other, a st...

Wild-type recombinant horseradish peroxidase purified and refolded from Escherichia coli inclusion bodies has been studied in the system of bis(2-ethylhexyl)sulphosuccinate sodium salt (Aerosol OT)-reversed micelles in octane. In contrast with native horseradish peroxidase the wild-type recombinant enzyme forms dimeric structures as judged by sedimentation analysis. Peroxidase substrates affect...

Co-polyimide nanofiber based on BPDA (3, 30 , 4, 40-Biphenyltetracarboxylic dianhydride)/PDA (p-Phenylene-diamine)/ODA (4, 40-Oxydianiline) (BPO) were produced by electrospinning followed by imidization from precursor polyamic acid (PAA) nanofiber. The aligned co-polyimide nanofiber mats possessed a modulus, strength and strain-at-break of respective 10 GPa, 1.04 GPa, and 13.5%. In comparison w...

Ferrocene solubilized with poly(vinylpyrrolidone) in aqueous KCl solution exhibited a well-defined voltammetric peak at 1.33 V vs. Ag|AgCl at a platinum electrode. The wave was attributed to the oxidation of chloride to chlorine, demonstrated by smell of chlorine, by a view of formation of gas bubbles, by coloration through the reaction with diethyl-p-phenylene diamine, and by the increase in t...