INTRODUCTION Different modalities have been used to achieve better results in wound healing among which are laser and pharmacological agents. To our knowledge, there is no investigation to compare phenytoin and laser together. In this study, we aimed to evaluate laser and phenytoin efficacy and compare their effect on wound healing. METHODS We used 60 rats. The animals were divided into 4 gro...

Context: Gingival overgrowth can be associated with pharmacotherapy. Among the offending medications of gingival overgrowth, phenytoin is the first reported and the most common agent. Evidence Acquisition: A literature search was performed with the relevant key words in different databases such as Scopus, Medline, Embase, and Google scholar. Results: About 50% of individuals receiving phenytoin...

We conducted a case control study to evaluate the effect of phenytoin and valproic acid on serum lipids and liver function tests in epileptic children. Seventy-nine children receiving at least 6 months of antiepileptic monotherapy were categorized into two groups, depending on whether they were receiving phenytoin or valproic acid. Age matched healthy controls were also included. The mean total...

Introduction: Post-traumatic seizures can occur as a complication of head injury, whether it is immediately after the injury to months or years after. Phenytoin an anti-epileptic drug that has been used widely prophylaxis for posttraumatic seizures. Method: The study was conducted retrospectively using medical records trauma patients in hospitals 2020-2022 on 54 samples treated up seven days po...

The antiarrhythmic effects of procainamide and phenytoin were studied in 81 patients admitted to the coronary care unit at the University Hospital in Linköping because of a suspected or proven diagnosis of acute myocardial infarction, and who developed ventricular arrhyhmias, requiring treatment, during the first 8 hours in hospital. Patients were randomly allocated to a procainamide of phenyto...

PURPOSE To evaluate a canine intestinal accessport model to study colonic absorption of drugs. The antiepileptic drugs phenytoin and gabapentin were chosen to study absorption of a lipophilic and hydrophilic compound, respectively. METHODS Drug plasma level-time plots were generated subsequent to small intestinal and colonic drug administration of both drugs. The poorly water-soluble phenytoi...

Summary. A 53-year-old Hispanic male with a history of seizure disorder was admitted for acute kidney injury (AKI) and rhabdomyolysis due to status epilepticus. He was managed with IV fluids and IV phenytoin. No breakthrough seizures occurred on admission and AKI quickly resolved. Twenty-four hours after therapeutic levels of serum phenytoin were reached, serum creatine kinase (CK) levels peake...

Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing both myocarditis and SJS in the same patient is very rare and can lead to increased morbidity and...

Present study was undertaken to determine if an interaction exists during co-administration of ciprofloxacin with phenytoin. Eight healthy male rabbits received oral phenytoin, 40 mg/kg, od, for 7 days. On day 7, phenytoin blood sampling was done at times 0, 0.1, 1, 2, 3, 4, 5, 6, 8 and 24 hr. From day 8 to 14, phenytoin was co-administered with oral ciprofloxacin, 70 mg/kg, od. On day 14, bloo...