نتایج جستجو برای: phospholipase a1

تعداد نتایج: 43781  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
María Lucas Andrew H Gaspar Chiara Pallara Adriana Lucely Rojas Juan Fernández-Recio Matthias P Machner Aitor Hierro

A challenge for microbial pathogens is to assure that their translocated effector proteins target only the correct host cell compartment during infection. The Legionella pneumophila effector vacuolar protein sorting inhibitor protein D (VipD) localizes to early endosomal membranes and alters their lipid and protein composition, thereby protecting the pathogen from endosomal fusion. This process...

2013
Lin Ma Jun Nagai Jerold Chun Hiroshi Ueda

BACKGROUND We previously reported that nerve injury-induced neuropathic pain is initiated by newly produced lysophosphatidic acid (LPA). RESULTS In this study, we developed a quantitative mass spectrometry for detecting LPA species by using Phos-tag. Following nerve injury, the levels of 18:1, 16:0 and 18:0 LPA in the spinal dorsal horn significantly increased at 3 h and declined at 6 h. Amon...

Journal: :Zhongguo fei ai za zhi = Chinese journal of lung cancer 2008
Juan Zhou Weimin Zhang Qianjun Ye Gang Jia

BACKGROUND Endothelin-1 (ET-1) is a potent mitogen involved in cell growth in human lung adenocarcinoma cells SPC-A1. The increase in intracellular free calcium ([Ca(2+)]i) plays a great role in this process. The aim of this study is to investigate the ET-1-induced [Ca(2+)]i responses in SPC-A1 cells and to explore its cellular mechanism. METHODS [Ca(2+)]i was measured by Fura-2/AM fluorescen...

2017
Michael A Casasanta Christopher C Yoo Hans B Smith Alison J Duncan Kyla Cochrane Ann C Varano Emma Allen-Vercoe Daniel J Slade

Fusobacterium nucleatum is an oral pathogen that is linked to multiple human infections and colorectal cancer. Strikingly, F. nucleatum achieves virulence in the absence of large, multiprotein secretion systems (Types I, II, III, IV, and VI), which are widely used by Gram-negative bacteria for pathogenesis. By contrast, F. nucleatum strains contain genomic expansions of Type V secreted effector...

Journal: :Molecular & cellular proteomics : MCP 2005
Noura Bensalem Ana Paula Ventura Benoît Vallée Joanna Lipecka Danielle Tondelier Noélie Davezac Alexandre Dos Santos Mauro Perretti Anne Fajac Isabelle Sermet-Gaudelus Michel Renouil Jean-François Lesure Frédéric Halgand Olivier Laprévote Aleksander Edelman

Cystic fibrosis is a fatal human genetic disease caused by mutations in the CFTR gene encoding a cAMP-activated chloride channel. It is characterized by abnormal fluid transport across secretory epithelia and chronic inflammation in lung, pancreas, and intestine. Because cystic fibrosis (CF) pathophysiology cannot be explained solely by dysfunction of cystic fibrosis transmembrane conductance r...

ژورنال: پژوهش در پزشکی 2010
جهانی شرافت, سمیه, فرنیا, پریسا, میرصمدی, النازالسادات , گودرزی, حسین ,

Abstract Background: The Beijing strain of Mycobacterium tuberculosis is responsible for more than 25% of cases of Tuberculosis in the world, it has a high transmission potential and there is a significant correlation between Beijing strain and multidrug resistance. In this study we compared the presence of Phospholipase C genes in Beijing and Nonbeijing strains of Mycobacterium tuberculosis...

2005
Noura Bensalem Ana Paula Ventura Benoı̂t Vallée Joanna Lipecka Danielle Tondelier Noélie Davezac Alexandre Dos Santos Mauro Perretti Anne Fajac Isabelle Sermet-Gaudelus Michel Renouil Jean-François Lesure Frédéric Halgand Olivier Laprévote Aleksander Edelman

Cystic fibrosis is a fatal human genetic disease caused by mutations in the CFTR gene encoding a cAMP-activated chloride channel. It is characterized by abnormal fluid transport across secretory epithelia and chronic inflammation in lung, pancreas, and intestine. Because cystic fibrosis (CF) pathophysiology cannot be explained solely by dysfunction of cystic fibrosis transmembrane conductance r...

2000
Eric Féraille Pascal Béguin Maria-Luisa Carranza Sandrine Gonin Martine Rousselot Pierre-Yves Martin Hervé Favre Käthi Geering Guido Guidotti

The a1 subunit of Na,K-ATPase is phosphorylated at Ser-16 by phorbol ester-sensitive protein kinase(s) C (PKC). The role of Ser-16 phosphorylation was analyzed in COS-7 cells stably expressing wild-type or mutant (T15A/S16A and S16D-E) ouabain-resistant Bufo a1 subunits. In cells incubated at 37°C, phorbol 12,13-dibutyrate (PDBu) inhibited the transport activity and decreased the cell surface e...

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