In Atomic force microscope (AFM) examination of a vibrating microcantilever, the nonlinear tip-sample interaction would greatly influence the dynamics of the cantilever. In this paper, the nonlinear dynamics and chaos of a tip-sample dynamic system being run in the tapping mode (TM) were investigated by considering the effects of hydrodynamic loading and squeeze film damping. The microcantileve...

Lipocalin-2 (Lcn2) is a biomarker for many inflammatory-based diseases, including acute kidney injury, cardiovascular stress, diabetes, and various cancers. Inflammatory transitions occur rapidly in kidney and cardiovascular disease, for which an in-line monitor could be beneficial. Microcantilever devices with aptamers as recognition elements can be effective and rapidly responsive sensors. He...

Direct, small-molecule determination of the antiepileptic drug, valproic acid, was investigated by a label-free, nanomechanical biosensor. Valproic acid has long been used as an antiepileptic medication, which is administered through therapeutic drug monitoring and has a narrow therapeutic dosage range of 50-100 μg·mL-1 in blood or serum. Unlike labeled and clinically-used measurement technique...

This study demonstrates a novel method for electrical detection of C-reactive protein (CRP) as a means of identifying an infection in the body, or as a cardiovascular disease risk assay. The method uses a single free-standing, thermally controlled piezoresistive microcantilever biosensor. In a commonly used sensing arrangement of conventional dual cantilevers in the Wheatstone bridge circuit, r...

The present work analyzes theoretically and verifies the advantage of utilizing rectangular microcantilevers with long-slits in microsensing applications. The deflection profile of these microcantilevers is compared with that of typical rectangular microcantilevers under the action of dynamic disturbances. Various force-loading conditions are considered. The theory of linear elasticity for thin...

Title of Document: MICROCANTILEVER BIOSENSORS WITH CHITOSAN FOR THE DETECTION OF NUCLEIC ACIDS AND DOPAMINE Stephan Koev, Master of Science, 2007 Directed By: Professor Reza Ghodssi Department of Electrical and Computer Engineering Abstract: Microcantilever biosensors allow label-free detection of analytes within small sample volumes. They are, however, often limited in sensitivity or specifici...

in this paper, a numerical solution procedure is presented for the forced vibration of a piezoelectric nanowire under thermo-electro-mechanical loads based on the nonlocal elasticity theory within the framework of timoshenko beam theory. using hamilton’s principle, the nonlocal governing differential equations are derived. the governing equations and the related boundary conditions are discreti...

We report two types of signal enhancement strategy derived from the origin of mechanical response, surface stress and mass, of the dynamic mode microcantilever for the detection of PSA at low picogram scales (low femtomolar concentration). The PSA detection at extremely low concentration levels is crucial to the early detection of relapses of prostate cancer after the radical prostatectomy and ...

The measurement of glucose is of great importance in clinical diagnosis. This is especially essential for the continuous monitoring for example in a patient suffering from diabetes mellitus which is caused by the high levels of glucose in human physiological fluid. Even though many research have been done for glucose measurement, there are still many research in progress to develop new methods ...

This paper presents the design and application of microcantilever heaters for biochemical applications. Thermal lysis of biological cells was demonstrated as a specific example. The microcantilever heaters, fabricated from selectively doped single crystal silicon, provide local resistive heating with highly uniform temperature distribution across the cantilevers. Very importantly, the microcant...