Iron is a critical nutrient for DNA synthesis and cellular proliferation. Targeting iron in cancer cells using specific chelators is a potential new strategy for the development of novel anticancer agents. One such chelator, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT), possesses potent and selective anticancer activity (J Med Chem 50:3716-3729, 2007). To elucidate the mechanisms of it...

MIT-BIH Database is the standard ECG database which is used universally for ECG analysis purpose. MIT-BIH database for normal sinus rhythm is sampled at 128 Hz and the data is available at uniform intervals of 7. 8125 ms. To use this data for analysis purpose with various techniques like artificial neural networks, correlation techniques etc. , it is required to have samples at desired interval...

Benign Intracranial Hypertension Benign Intracranial Hypertension (BIH) has been reported in 1 in 1000 children receiving GH treatment. It is possibly due to the increase in salt and water retention that sometimes happens when starting GH treatment. In this condition, the pressure inside the head increases and children may complain of headache, loss of vision, nausea or vomiting. BIH usually de...

Spatial Contrast Sensitivity (CS) was studied in 20 patients with benign intracranial hypertension (BIH). At presentation CS loss was found in 43% of the eyes, and impairment of visual acuity attributed to BIH in only 16%. Nine patients had blurred vision or visual obscurations, all of whom had abnormal CS. The clinical application of CS measurement in BIH for monitoring the progression or regr...

The International Classification of Headache Disorders-third edition beta (ICHD-3 beta), defines the postictal headacheas “headache caused by and occurring within 3 hours after an epileptic seizure, and remitting spontaneously within 72 hours after seizure termination”. People at highest risk of suffering PIH are who have generalized tonic-seizures (GTCSs) and a history of interictal headaches....

OBJECTIVES To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS). METHODS Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined. RESULTS The i...

Gallium nitrate is active against lymphoma and bladder cancer; however, little is understood about tumor resistance to this drug. Transferrin, the iron transport protein, increases gallium uptake by cells, whereas pyridoxal isonicotinoyl hydrazone (PIH), an iron chelator, transports iron into cells. Therefore, we examined whether these metal transporters would increase the cytotoxicity of galli...

Background: Pregnancy Induced Hypertension (PIH) is a significant contributor to various pregnancy complications. Therefore, an effective way avoid possible fatal complications of the disease create awareness among pregnant women. Pregnant women who are aware danger signs will take responsibility for seeking medical attention if any arise. However, there lack study done at public hospitals in S...