In this review the controversy regarding the association between topical pimecrolimus and tacrolimus and the development of tumors is unfolded. After reviewing the literature we conclude that, currently, there is no scientific evidence of an increased incidence of skin cancer, lymphomas or systemic immunosuppression in those patients that use or have used topical calcineurin inhibitors. Publish...

In dermatological therapy, a basic group of drugs with immunosuppressive and anti-inflammatory effects is the glucocorticoids. Their mechanism of action may lead to numerous side effects. The discovery of cyclosporin A, tacrolimus and pimecrolimus has created an alternative to steroid therapy in dermatology. A common feature of calcineurin inhibitors is inhibition of the activity of immunocompe...

The speaker gave a brief review of published reports on the medical therapy of vitiligo in the last five years. First of all, the use of topical agents was discussed. Fifty percent of the patients had more than 75% of their lesions repigmented after 0.1% tacrolimus treatment. The efficacy was comparable to clobetasol propionate. There was limited data on pimecrolimus but a trial showed that its...

BACKGROUND Lichen sclerosus is a chronic, inflammatory skin condition that most commonly occurs in adult women, although it may also be seen in men and children. It primarily affects the genital area and around the anus, where it causes persistent itching and soreness. Scarring after inflammation may lead to severe damage by fusion of the vulval lips (labia); narrowing of the vaginal opening; a...

Psoriasis vulgaris is a chronic, multisystem, genetic, noncontagious inflammatory disorder. Psoriasis limited to the glans penis is a rare presentation. We present two patients with penile involvement and absence of psoriatic lesions elsewhere on the body, which led to delay of diagnosis. Due to the specific localization, the treatment of choice was the calcineurin inhibitor pimecrolimus 1% crè...

Citation: Takahashi H, Satoh K, Takagi A, Ishida-Yamamoto A, Iizuka H (2015) Successful Treatment of Annular Elastolytic Giant Cell Granuloma with Tranilast and Topical Glucocorticoid under the Strict Restriction of Sun Exposure. Int J Dermatol Clin Res 1(2): 014-015. DOI: 10.17352/2455-8605.000006 014 various therapeutic modalities including intralesional and systemic glucocorticoids, psoralen...

Allergic contact dermatitis (ACD) may account for at least 20% of all childhood dermatitis. Clinically, its morphology is identical to other forms of dermatitis in acute, subacute and chronic forms. A persistent or unusual and localized pattern is often the key to diagnosis. Treatment has centered around the use of corticosteroids, with the adjunct of antihistamines, wet dressings, and emollien...