Abstract Background Magnesium sulphate (MgSO 4 ) has been proven as an analgesic, neuromuscular blocker agent, and treatment of acute asthma. Objective The study aimed to assess the safety efficacy magnesium infusion for patients with atrial fibrillation. Methods A prospective, randomized, double-blind, placebo-controlled was conducted on 55 fibrillation at Emergency Department. group consistin...

Background: Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular disease. We investigated whether sleeping at altitude increases nocturnal heart rate (HR) and other markers of risk or arrhythmias in lowlanders COPD this can be prevented by oxygen therapy (NOT). Methods: Twenty-four patients, median age 66 years forced expiratory volume 1 s (FEV ) 55% predicted, living ...

To evaluate efficacy and safety of budesonide oral suspension (BOS) in pediatric patients with eosinophilic esophagitis (EoE). We used pooled data from two 12-week, randomized, double-blind, placebo-controlled trials BOS 2.0 mg b.i.d. (phase 2 [MPI 101-06/NCT01642212] phase 3 [ORBIT1/SHP621-301/NCT02605837]) aged 11–17 years EoE dysphagia. Peak eosinophil counts, the Dysphagia Symptom Questionn...

BackgroundBerotralstat (BCX7353) is a recently approved, oral, once-daily kallikrein inhibitor for hereditary angioedema (HAE) prophylaxis. In the APeX-2 trial, berotralstat reduced HAE attack rates over 24 weeks, with favorable safety and tolerability profile.ObjectiveEvaluate safety, tolerability, effectiveness 48 weeks.MethodsAPeX-2 phase 3, parallel-group, multicenter trial (NCT03485911) in...

Aim To evaluate the efficacy, safety, and tolerability of apararenone 10 mg/day in patients with nonalcoholic steatohepatitis (NASH). Methods In this multicenter, randomized, double-blind, placebo-controlled phase II study, received mg or placebo once daily for 72 weeks. The primary efficacy end-point was percent change serum alanine aminotransferase (ALT) from baseline to 24 weeks after random...

The aim of this study was to investigate the influence ADORA2A and CYP1A2 genotypes on physiological ergogenic effects caffeine. Sixty-six male cyclists were screened for genotypes; with 40 taking part subsequently in a randomised, double-blind, placebo-controlled study. Trial 1 used establish oxygen uptake?power output relationship maximal uptake. In trials 2 3, participants ingested 5 mg·kg ?...

Abstract Background Bacterial infection is an important cause of diarrhea in children, potentially leading to malnutrition, growth and development disorders, even death. Antibiotic abuse resistance are widespread problems worldwide, especially China. We therefore designed a study evaluate the clinical efficacy mechanism traditional Chinese medicine alleviating effects antibiotic childhood bacte...

TA-65 is a small molecule telomerase activator extracted from Astragalus species. A previous observational study suggested that decreased the number of immunosenescent cells in healthy subjects. Here we examined impact much larger randomized, double-blind, and placebo-controlled study. This aims to evaluate effects on senescent CD8+CD28- T was placebo-controlled, multi-arm parallel trial 500 Su...

In a randomized, head-to-head, placebo-controlled trial, we enrolled adults with obesity (body-mass index [the weight in kilograms divided by the square of height meters], 32 to 43) who did not have diabetes. After an 8-week low-calorie diet, participants were randomly assigned for 1 year one four strategies: moderate-to-vigorous–intensity exercise program plus placebo (exercise group); treatme...

Abstract Background Major depressive disorder is the second leading cause of years lost to disability worldwide. Anyu Peibo Capsule has been shown be effective and safe in phase II trials. Methods This clinical study a multi-center, randomized, double-blinded, placebo-controlled, parallel-group, III trial China. The aim test whether administration compared placebo improves outcomes adults (aged...