BACKGROUND To investigate beneficial effects of Pomegranate seeds oil (PSO), leaves (PL), juice (PJ) and (PP) on brain cholinesterase activity, brain oxidative stress and lipid profile in high-fat-high fructose diet (HFD) induced-obese rat. METHODS In vitro and in vivo cholinesterase activity, brain oxidative status, body and brain weight and plasma lipid profile were measured in control rats...

Cholinesterase-inhibiting pesticides are applied throughout Australia to control agricultural pests. Blood plasma cholinesterase (ChE) activity is a sensitive indicator of exposure to organophosphorus insecticides in vertebrates. To aid biomonitoring and provide reference data for wildlife pesticide-risk assessment, plasma acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities ...

This study was undertaken to examine the correlation, if any, between the inhibition of red blood cell cholinesterase (RBC ChE), plasma cholinesterase (PChE) and cerebrospinal fluid acetyl cholinesterase (CSF AChe) and the severity of symptoms in patients poisoned with organophosphorus (OP) compounds. Baseline values of the cholinesterases (RBC, Plasma & CSF) were established in our laboratory ...

Human plasma to be analyzed for exposure to cholinesterase inhibitors is stored at 4 °C or lower to prevent denaturation of human butyrylcholinesterase (HuBChE), the biomarker of exposure. Currently published protocols immunopurify HuBChE using antibodies that bind native HuBChE before analysis by mass spectrometry. It is anticipated that the plasma collected from human casualties may be stored...

Pseudocholinesterase (PChE), also known as plasma cholinesterase, is a serine hydrolase capable of hydrolyzing esters including acetylcholine, succinylcholine, mivacurium and ester type local anesthetics such as procaine, chloroprocaine, tetracaine, cocaine and heroin. PChE is synthesized by the liver, and is found in the plasma, the pancreas, the heart and the brain. It has a serum half life o...

objective(s): in this study, the effects of crocin against subchronic toxicity of diazinon (dzn) on systolic blood pressure (sbp) and heart rate (hr) were evaluated in rats. materials and methods: rats were equally divided into 7 groups; control (corn oil), dzn (15 mg/kg), crocin (each group received 12.5, 25 or 50 mg/kg crocin plus dzn), vitamin e (200 iu/kg plus dzn) and crocin (50 mg/kg) tre...

The cholinergic system is known to show deterioration during aging and Alzheimer's disease. In response, a therapeutic approach to Alzheimer's disease has been to attempt to compensate for the decrease in central cholinergic function by potentiating the activity of the remaining intact cholinergic cells with cholinesterase inhibitors. In this study treatment with the long-lasting cholinesterase...