The prevalent view is that the postabsorptive plasma glucose concentration is maintained within the physiological range by the interplay of the glucose-lowering action of insulin and the glucose-raising action of glucagon. It is supported by a body of evidence derived from studies of suppression of glucagon (and insulin, among other effects) with somatostatin in animals and humans, immunoneutra...

The effect of hemolysis on the concentration of insulin in plasma was studied by a radioimmunoassay method. Plasma specimens with hemolysis have apparently lower insulin concentrations than plasma specimens without hemolysis, probably owing to the ability of red cell constituents to degrade insulin. The effects of hemolysis on the radioimmunoassay of insulin are quantitated, and the necessity o...

We examined the cross-sectional association between plasma 25-hydroxyvitamin D [25(OH)D] and markers of the insulin resistant phenotype. Plasma 25(OH)D concentrations were measured in 808 nondiabetic participants of the Framingham Offspring Study. Outcome measures included fasting and 2-h post 75-g oral glucose tolerance test (OGTT) glucose and insulin; these were used to calculate the homeosta...

The present report concerns several post-mortem variables examined in sand rats that were either maintained on a vegetal diet (control animals) or exposed first during a 20-day transition period to a mixed diet consisting of a fixed amount of a hypercaloric food and decreasing amounts of the vegetal food and then to a 30-day experimental period of exposure to the hypercaloric food. During the l...

Introduction: Ghrelin is a peptide hormone secreted from the stomach with both endocrine and paracrine effects. Ghrelin and its mRNA as well as growth hormone (GH) secretagogue receptor mRNAs are expressed in the pancreas and islet cells and regulate insulin release. Also the immounoreactivity of ghrelin is proved to be high in the hypothalamus and parts of the brain responsible for the re...

We investigated the dose- and time-dependent effect of insulin infusion on peripheral and portal plasma leptin concentrations in normal rats. Three groups were studied: group I: euglycemic (6 mmol/l) insulin (6 mU ⋅ kg-1 ⋅ min-1) clamps for 0, 2, 4, 12, and 24 h; group II: euglycemic insulin (18 mU ⋅ kg-1 ⋅ min-1) clamp for 2 h; and group III: euglycemic insulin (3 mU ⋅ kg-1 ⋅ min-1) clamp for ...

This study was performed in 36 healthy volunteers to define the relationship between plasma concentrations of partially oxidized low density lipoprotein (poxLDL), plasma glucose and insulin responses to oral glucose, and steady-state plasma glucose (SSPG) concentrations after a 180-minute infusion of somatostatin, insulin, and glucose. The concentration of poxLDL was estimated by determining th...

This paper works a new approach to regulate the blood glucose level of diabetes. We proposed a new mathematical model for the study of diabetes mellitus. The model takes into account all plasma glucose concentration, generalized insulin and plasma insulin concentration. The numerical solution presents the complex situation of diabetic patients. Computer simulations are used to evaluate the effe...

objective: diabetes is a common endocrine disorder caused by deficiency of insulin secretion or insulin resistant. nowadays, in addition to trying to find a safe way to control diabetes, find the low side effect way is important. this study was designed to find the effect of urtica dioica extract on glycemic control and insulin resistance in patients with type 2 diabetes. materials and methods:...

It recently has been hypothesized that increased plasma plasminogen activator inhibitor-1 (PAI-1) activity could be a possible link between insulin resistance and coronary heart disease. However, it is not known whether insulin sensitivity per se is a determinant of plasma PAI-1 activity or whether other intermediates could explain this association. We investigated the relationship between plas...