Polygonum multiflorum stilbeneglycoside (PMS) is a water-soluble fraction of Polygonum multiflorum Thunb., one of the most famous tonic traditional Chinese medicines, that has protective effects on the cardiovascular system. The purpose of the present study is to elucidate the effects of PMS on macrophage-derived foam cell functions and the reduction of severity of atherosclerosis in hyperchole...

Bubali Cornu (water buffalo horn, WBH) has been used for thousands of years in traditional Chinese medicine (TCM) as an effective treatment for heat. In the present study, we have carried out a metabolomics profiling study on plasma and urine samples to explore potential biomarkers and determine how WBH exerts its antipyretic effects in yeast-induced pyrexia at a metabolomic level. Ultra-high p...

Asthma is a chronic inflammatory disorder of the airway and is characterized by airway remodeling, hyperresponsiveness, and shortness of breath. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicines (TCM), has been demonstrated to have good therapeutic effects on experimental allergic asthma. However, its anti-asthma mechanism remains currently unknown. In the ...

This article profiles ten examples of chemicals derived from herbal preparations that influence ionotropic receptors for the brain’s major inhibitory neurotransmitter g-aminobutyric acid (GABA). Many herbal medicines are used to influence brain function in order to treat anxiety, cognitive disorders, and insomnia. Such disorders are considered likely to involve GABA receptors, particularly iono...

Essential medicines are those that satisfy the priority healthcare needs of the population and are available at all times in adequate amounts, in the appropriate dosage forms with assured quality and at a price the individual and community can afford. Essential medicines are selected with due regard to disease prevalence, efficacy, safety and cost effectiveness. In most developing countries, th...

The first WHO essential drugs list, published in 1977, was described as a peaceful revolution in international public health. The list helped to establish the principle that some medicines were more useful than others and that essential medicines were often inaccessible to many populations. Since then, the essential medicines list (EML) has increased in size; defining an essential medicine has ...

The updated list adds 30 medicines for adults and 25 for children, and specifies new uses for 9 already-listed products, bringing the total to 433 drugs deemed essential for addressing the most important public health needs. The WHO Essential Medicines List (EML) is used by many countries to increase access to medicines and guide decisions about which products they ensure are available for thei...

BACKGROUND Research findings are increasingly being recognized as an important input in the formation of health policy. There is concern that research findings are not being utilized by health policy-makers to the extent that they could be. The factors influencing the utilization of various types of research by health policy-makers are beginning to emerge in the literature, however there is sti...

objective: visfatin, is a novel adipokine, and an adipose tissue-derived hormone shown to correlate with visceral fat mass in patients with obesity. it is not well known whether endurance training – induced change in adipose tissue and blood lipids decreases plasma visfatin or not; thus, the purpose of this study was to examine the effect of 12 weeks endurance training on plasma visfatin in men...

BACKGROUND In August 2009, China formally established the National Essential Medicines System (NEMS) and implemented this system in the government-funded primary care medical and health institutions. After nearly four years of practice, the system has already been generalized to the county-level public hospitals. This study aimed to examine the impact on the operation of the hospitals through i...