Hereditary angioedema is a rare genetically determined disease characterized by the recurrent of various localizations with no response to systemic glucocorticosteroids, antihistamines.
 In majority hereditary cases C1-inhibitor level or its functional activity decreased due mutation in SERPING1 gene. recent years, expansion genetic diagnostic recourses significantly changed our understand...

Pregnancy is a hypercoagulable state secondary to an increase in coagulation factors, reduction naturally occurring anticoagulants, and impairment of fibrinolysis. losses were divided into preclinical, first trimester clinical, second trimester. A meaningfully increased rate preclinical pregnancy failure Leiden mutation carriers was found than no activated protein C deficiency patients. Another...

PURPOSE The local deposition of fibrinogen and other plasma products from tears within corneal wounds and the expression of plasminogen activator by corneal epithelial cells suggest that the coagulation and fibrinolytic systems play an important role in corneal wound healing. The authors used mouse lines deficient in plasminogen (Plg), fibrinogen (Fib), or both to elucidate the roles of these k...

The fibrinolytic system of a patient with congenital deficiency of a2-proteinase (plasmin) inhibitor (a2Pl) was studied. The patient’s whole blood clot formed in vitro was lysed rapidly in several hours on incubation. This accelerated in vitro fibrinolysis was suppressed by an addition of purified a2Pl. The degree of suppression was proportional to the amount of a2PI added. In spite of the acce...

The fibrinolytic system of a patient with congenital deficiency of a2-proteinase (plasmin) inhibitor (a2Pl) was studied. The patient’s whole blood clot formed in vitro was lysed rapidly in several hours on incubation. This accelerated in vitro fibrinolysis was suppressed by an addition of purified a2Pl. The degree of suppression was proportional to the amount of a2PI added. In spite of the acce...