Research into the aetiological agent of the most widespread form of severe malaria, Plasmodium falciparum, has benefitted enormously from the ability to culture and genetically manipulate blood-stage forms of the parasite in vitro. However, most malaria outside Africa is caused by a distinct Plasmodium species, Plasmodium vivax, and it has become increasingly apparent that zoonotic infection by...

Malaria is a disease caused by Plasmodium spp. protozoa. The ability of to develop resistance current antimalarial drugs makes the study chemotherapeutic alternatives extremely important. This aimed evaluate activity compound 3286938 (1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one), which presents in its structure 3,4,5-trimethoxyphenyl group, vitro, using W2 strain P...

introduction: malaria is a protozoal disease, transmitted to humans by female anopheles mosquito bite. plasmodium falciparum, compared to other kinds of plasmodium, causes more severe malaria and is associated with a higher mortality rate. annually, one to three million deaths occur due to malaria, especially by p. falciparum. case presentation: in this report, we introduce an iranian patient s...

The declining efficacy of artemisinin derivatives against Plasmodium falciparum highlights the urgent need to identify alternative highly potent compounds for the treatment of malaria. In Papua Indonesia, where multidrug resistance has been documented against both P. falciparum and P. vivax malaria, comparative ex vivo antimalarial activity against Plasmodium isolates was assessed for the artem...

BACKGROUND Recent reports of Plasmodium vivax associated with severe syndromes and mortality from malaria endemic areas questions the "benign" course of non-falciparum malarias. METHODS We retrospectively analyzed data from patients reported to the US Centers for Disease Control and Prevention with a diagnosis of malaria parasite single-species infection between 1985 and 2011. Patients classi...

Rapid diagnostic tests (RDTs) capable of detecting and differentiating Plasmodium species are needed in areas in which microscopy is unsuitable. This study was conducted to assess the diagnostic performance of the rapid test kit - SD BIOLINE Malaria Ag Pf/Pan(r) (05FK60) in an endemic area. Microscopy of Giemsa-stained blood films were performed to detect and estimate the Plasmodium density in ...

background : the aim of the study was to identify the prevalence of different species of plasmodium and haplotypes of pfcrt in plasmodium falciparum from the selected area. methods : overall, 10,372 blood films of suspected malarial patients were examined microscopically from rural health center sinawan, district muzaffargarh, pakistan from november 2008 to november 2010. p. falciparum positive...

INTRODUCTION Acalculous cholecystitis has been shown to occur in the context of malarial infection with Plasmodium vivax and Plasmodium falciparum and requires prompt diagnosis and treatment to prevent complications. To the best of our knowledge this is the first reported case of the disease occurring in a patient infected with Plasmodium malariae. CASE PRESENTATION We report the first case o...

The genome of the malarial parasite Plasmodium falciparum is extremely AT rich. This bias toward a low GC content is a characteristic of several, but not all, species within the genus Plasmodium. We compared 4283 orthologous pairs of protein-coding sequences between Plasmodium falciparum and the less AT-biased Plasmodium vivax. Our results indicate that the common ancestor of these two species ...

PLASMODIUM FALCIPARUM EBL PROTEINS by JOHN VINCENT STOKES (Under the Direction of David S. Peterson) ABSTRACT While heterologous expression has replaced biochemical purification as the principle method for obtaining purified, authentic proteins for characterization, no single expression system has proven appropriate for all applications. Heterologous expression of Plasmodium falciparum genes ha...