BACKGROUND Pediatric Bipolar Disorder (PBD) is a debilitating condition associated with impairment in many domains. Social functioning is one of the disorder's most notable areas of impairment and this deficit may be in part due to difficulties recognizing affect in others. METHODS In the present study, medication naïve youth with PBD were compared to age-matched healthy controls on their abi...

BACKGROUND AND STUDY AIMS Selective biliary cannulation is unsuccessful in 5 % to 10 % of patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) for malignant distal biliary obstruction (MDBO). Percutaneous biliary drainage (PBD) has been the gold standard, but endoscopic ultrasound guided rendezvous (EUSr) have been increasingly used for biliary decompression in this patient...

BACKGROUND The U.S. Centers for Disease Control and Prevention collected health, housing, and environmental data in a single integrated national survey for the first time in the United States in 1999-2004. OBJECTIVES We aimed to determine how floor dust lead (PbD) loadings and other housing factors influence childhood blood lead (PbB) levels and lead poisoning. METHODS We analyzed data from...

Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers are synthetic sequence-selective DNA minor-groove cross-linking agents that possess two electrophilic imine moieties (or their equivalent) capable of forming covalent aminal linkages with guanine C2-NH(2) functionalities. The PBD dimer SJG-136, which has a C8-O-(CH(2))(3)-O-C8'' central linker joining the two PBD moieties, is currently undergoing p...

M. H. Skolnick et at. (1) obtained specimens by multiple fine-needle aspiration from the breasts of women with and without a family history of breast cancer. They assessed the prevalence of certain cytologic changes in these groups of women, which they labeled proliferative breast disease (PBD). Skolnick et al.'s use of this term is unfortunate because PBD is a well-recognized histologic diagno...

The present study is an extension of the cooperative kinematics (CK) approach (Bahar, I.; Erman, B.; Monnerie, L.Macromolecules 1992, 25, 6309), which has been demonstrated to give an efficient and realistic account of the mechanism of local relaxational processes in polyethylene (PE). In the present work, the effects of (i) departure from tetrahedral backbone geometry and (ii) differences in t...

With the increasing use ofprefabricated vertical drains in the improvement of soft clay there are many types of these drains, both composite (with geotextile wrapping) and monolithic (without geotextile wrapping), available in Malaysia. Some engineers have the impression that all drains perform satisfactorily. However, case studies have shown that there are cases where vertical drains failed to...

OBJECTIVE To use functional neuroimaging to probe the affective circuitry dysfunctions underlying disturbances in emotion processing and emotional reactivity in pediatric bipolar disorder (PBD). METHOD Equal numbers of controls (HC) and unmedicated patients with euthymia and PBD were matched for age, sex, race, socioeconomic status, and IQ (n = 10 per group; mean age 14.2 years [SD 2.0 years]...

We obtained unanticipated synthetic byproducts from alkylation of the δ(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. For the highest-affinity byproduct, bearing a C(6)H(5)(CH(2))(8)- group, a Plk1 PBD cocrystal structure revealed a new binding channel that had previously been occluded. An N-terminal PEGylated ver...