Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)2], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor activity relationship generally accepted for platinum(II) complexes. According to this relationship, only the cis geometry of leaving ligands in the bifunctional platinum(II) complexes, should be therapeuti...

Four platinum(II) complexes bearing a boron-based PBP pincer ligand and chloride, hydride, triflate, and bis(trifluoromethanesulfonyl)imide were synthesized and structurally characterized. PBP-platinum chloride was proven to be an active catalyst for the hydrosilylation reaction using 1-decene and triethylsilane.

A series of water-soluble /V-substituted iminodiacetato(l,2-diaminocyclohexane)-platinuin(H) complexes (IDP) were synthesized and tested for chemical stability, antitumor activity, and toxicity. The results ob tained suggest that these complexes are relatively stable for more than 48 h when dissolved in water or phosphate buffer. All complexes had good in vitro cytotoxicity and were not cross-r...

Platinum(II) diimine complexes with naphthalimide substituted fluorenylacetylide ligands are synthesized and characterized. The complexes exhibit long-lived (3)ILCT or (3)ILCT/(3)MLCT/(3)LLCT excited states (τ = ~20-30 μs) and broadband triplet transient absorption in the visible-NIR region. Nonlinear transmission experiments at 532 nm demonstrate that these complexes are efficient nonlinear ab...

Platinum(IV) coordination complexes like oxoplatin (cis,cis,trans-diammine-dichlorido-dihydroxido-platinum[IV]) show high stability and therefore can be utilized orally for outpatient care. Although oxoplatin is capable of binding directly to DNA after prolonged incubation, platinum(IV) agents are considered to be largely inert prodrugs that are converted to highly cytotoxic platinum(II) compou...

Reports on toxic effects of platinum coordination complexes on the endocrine pancreas are missing with exception of cis-DDP itself (Goldstein et al 1983). Recently, oxoplatin (trans-dihydroxy-cis-dichlorodiammine-platinum [IV]) an oxygenated derivative of cis-DDP has been described by Presnov and Konovalova (1988), Fig. 1. As indicated by the maximally tolerated dose levels, oxoplatin has been ...

Chantitative relationship beween activity and structure of antitumor platinum complexes was studied by C W / 2 method. On the basis of the obtained regression results, some new platinum complexes with methyl substituted aliphatic and cycloaliphatic mines were synthesized and screened, and a new complex [Pt(~PDA)(Cl-Ac),l possessing high activity as cisplatin but with much laver toxicity was fou...

Phenyl-2,6-bis(oxazole) ligands have been explored for the synthesis of novel palladium(II) and platinum(II) pincer complexes. The materials were characterized by spectroscopic methods and by X-ray crystallography. Investigations of the photophysical properties revealed that the lowest triplet states of the materials are largely centred at the bis(oxazole) ligands. The platinum(II) compounds ar...

The title cyclo-metalated platinum(II) complex with 2-(4-bromo-phen-yl)pyridinato and acetyl-acetonato ligands, [Pt(C11H7BrN)(C5H7O2)], consists of two crystallographically non-equivalent dimers, each stacked by π-π inter-actions with distances of ≃ 3.4 Å. In both dimers, the platinum(II) complexes are arranged anti-parallel to each other. Each complex exhibits a slightly distorted square-plana...

Four 1,5-naphthyridin-4-ol-containing platinum complexes, AtFOND, AtFNND, PBSOND, and PBSNND, have been synthesized characterized for their photoluminescence (PL) electroluminescence (EL) properties.