Partial least squares (PLS) has proven to be a important multivariate analytic tool for positron emission tomographic and, more recently, event-related potential (ERP) data. The application to ERP incorporates the ability to analyze space and time together, a feature that has obvious appeal for event-related functional magnetic resonance imaging (fMRI) data. This paper presents the extension of...

Primary lateral sclerosis (PLS) has been regarded as a rare, extreme form of amyotrophic lateral sclerosis (ALS). Like ALS, it is a clinical diagnosis without established biomarkers. We sought to explore loss of cerebral myelin in relation to clinical features, including cognitive impairment, in cases of both ALS and PLS. A novel MRI sequence (mcDESPOT) sensitive to water pools within myelin an...

In many domains (marketing, social sciences, etc.) the variables of interest are often not directly observable. Complex causal relationships between such latent variables may be modeled by means of Structural Equation Models (SEM). Two different methodologies exist for the estimation of such models: SEM-ML (Maximum Likelihood Approach to Structural Equation Models), also known as LISREL (Linear...

A multivariate dominant factor based non-linearized PLS model is proposed. The intensities of different lines were taken to construct a multivariate dominant factor model, which describes the dominant concentration information of the measured species. In constructing such a multivariate model, non-linear transformation of multi characteristic line intensities according to the physical mechanism...

Plasmalogens (Pls) belong to a subclass of glycerophospholipids, and widely distributed in human and animal tissues (Nagan & Zoeller, 2001). Although the clinical significance of these phospholipids is recognized in relation to peroxisomal disorders (Wanders & Waterham, 2006), the physiopathological roles of Pls are not fully understood. Recently, serum (or plasma) Pls have gained interest in s...

An important question in plant biology is how genes influence the crosstalk between hormones to regulate growth. In this study, we model POLARIS (PLS) gene function and crosstalk between auxin, ethylene and cytokinin in Arabidopsis. Experimental evidence suggests that PLS acts on or close to the ethylene receptor ETR1, and a mathematical model describing possible PLS-ethylene pathway interactio...

Aim of the Study. The three conventional pulse-diagnostic palpation locations (PLs) on both wrists are Cun, Guan, and Chi, and each location reveals different clinical information. To identify anatomical or hemodynamic specificity, we used ultrasonographic imaging to determine the arterial diameter, radial artery depth, and arterial blood flow velocity at the three PLs and at nearby non-PL segm...

OBJECTIVE To assess the importance of considering decision uncertainty, the appropriateness of probabilistic sensitivity analysis (PSA), and the use of patient-level simulation (PLS) in appraisals for the National Institute for Health and Clinical Excellence (NICE). METHODS Decision-makers require estimates of decision uncertainty alongside expected net benefits (NB) of interventions. This re...

background: papillon-lefevre syndrome (pls) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive pe-riodontitis. although cathepsin c (ctsc) gene mutations have been established in about 70-80% of pls patients, it is assumed that the patients may have dysfunctioning of immune defense mechanisms. objective: to assess the associat...

Purpose ‒ There is an increasing number of digital ṣukūk issuances worldwide but the level awareness and adoption in Nigeria very low. This research examines mediating effect on relationship between attitude, subjective norm, perceived behavioural control Nigeria. Design/Methodology/Approach The data for were collected from 750 questionnaires that distributed using systematic sampling technique...