Our previous studies have demonstrated that surfaceactive copolymers of Pluronic® surfactants and tertiary amino polycations such as poly (2-dimethylaminoethyl methacrylate) (PDMA) possess an enhanced DNA transfection efficiency compared to PDMA homopolymers. In order to understand the mechanism of such action, we conducted model studies of the interaction of polymer with phospholipid vesicles ...

Here, we produce poly(lactide-co-glycolide) (PLGA) based microparticles with varying morphologies, and temperature responsive properties utilizing a Pluronic F127/dextran aqueous two-phase system (ATPS) assisted self-assembly. The PLGA polymer, when emulsified in Pluronic F127/dextran ATPS, forms unique microparticle structures due to ATPS guided-self assembly. Depending on the PLGA concentrati...

For the treatment of intestinal tumors by oral administration drugs, mucus layer intestine represents a barrier, but also target possibility for drug. The use nanoparticular drug delivery systems is an important tool to improve transport and accumulation on side. Therefore, specific in vitro test simulate conditions tumor are necessary screening efficiency testing potential new systems. Here, w...

Copolymers, particularly Pluronics®, are typically used to sterically stabilise colloidal nanostructured particles composed of a lyotropic liquid crystalline bicontinuous cubic phase (cubosomes). There is a need to design and assess new functionalisable stabilisers for these colloidal drug delivery systems. Six amphiphilic brush copolymers, poly(octadecyl acrylate)-block-poly(polyethylene glyco...