In modern times, protein drugs have had an ever-increasing ability to efficiently combat disease in the human body, and delivery of polypeptide agents, whether insulin or interferons, to biological targets has thus become a task of great importance to doctors and patients alike. For this reason, it is the goal of many medical researchers to preserve the bioactivity of specific protein drugs and...

The ever-increasing demand for natural products and biotechnology derived from bees and ultra-modernization of various analytical devices has facilitated the rational and planned development of biotechnology products with a focus on human health to treat chronic and neglected diseases. The aim of the present study was to prepare and characterize polymeric nanoparticles loaded with Brazilian red...

Carvedilol (CAR) is a potent antihypertensive drug but has poor oral bioavailability (24%). A nanosuspension suitable for pulmonary delivery to enhance bioavailability and bypass first-pass metabolism of CAR could be advantageous. Accordingly, the aim of this work was to prepare CAR nanosuspensions and to use artificial neural networks associated with genetic algorithm to model and optimize the...

Onion intake might reduce the risk of colorectal cancer, according to epidemiology. However, Femia showed in 2003 that diets with 20% onion increase carcinogenesis in rats. We speculated this dose was too high. Prevention of initiation was thus tested in sixty rats given a 5% dried onion diet or AIN76 diet, and initiated 12d later with azoxymethane (AOM, 1x20mg/kg i.p.), 2-amino-3-methylimidazo...

Resorbable calcium phosphate based bone void fillers should work as temporary templates for new bone formation. The incorporation of macropores with sizes of 100 -300 µm has been shown to increase the resorption rate of the implant and speed up bone ingrowth. In this work, macroporous brushite cements were fabricated through foaming of the cement paste, using two different synthetic surfactants...

OBJECTIVE The objective of this study is to develop and characterize in situ thermosensitive gels for the vaginal administration of sildenafil as a potential treatment of endometrial thinning occurring as a result of using clomiphene citrate for ovulation induction in women with type II eugonadotrophic anovulation. While sildenafil has shown promising results in the treatment of infertility in ...

Background: Although microemulsion-based nanoparticles (MEs) may be useful for drug delivery or scavenging, these benefits must be balanced against potential nanotoxicological effects in biological tissue (bio-nano interface). We investigated the actions of assembled MEs and their individual components at the bio-nano interface of thrombosis and hemolysis in human blood. Methods: Oil-in-water M...

Cinnamaldehyde, the bioactive component of the spice cinnamon, and its derivatives have been shown to possess anti-cancer activity against various cancer cell lines. However, its hydrophobic nature invites attention for efficient drug delivery systems that would enhance the bioavailability of cinnamaldehyde without affecting its bioactivity. Here, we report the synthesis of stable aqueous suspe...

Aqueous solutions of commercial poly(oxyethylene) – poly(oxypropylene) – poly(oxyethylene), triblock co-polymers (PEOx – PPOy – PEOx, Pluronics©) undergo both micellization and structural arrangement as a function of increasing temperature. In the case of Pluronic F127 (PEO100 – PPO65 – PEO100), this structural arrangement is observed macroscopically as a liquid to gel transition for polymer co...

Cancer is a major cause of mortality in the modern world, with more than 10 million new cases every year. This outline is expected to rise in the next few decades since the majority (59%) of people diagnosed with cancer is aged over 65. In fact, around one in three people will be diagnosed with cancer throughout their lifetime (Siegel et al., 2012; Bosetti et al., 2013). The foundation of cance...