The rapid renal clearance of penicillin has made it difficult to maintain blood levels adequate to combat resistant organisms such as enterococci and many staphylococci. Diodrast (1), p-amino-hippurate (PAH) (2), benzoic acid (3), sodium benzoate (3, 4), and carinamide (5), have been found to block renal tubular excretion of penicillin with enhancement of blood levels. Of these compounds, only ...

We have analysed the distribution of inclination-corrected galaxy concentrations in the Sloan Digital Sky Survey. We find that unlike most galaxy properties, which are distributed bimodally, the distribution of concentrations is trimodal: it exhibits three distinct peaks. The newly-discovered intermediate peak, which consists of early-type spirals and lenticulars, may contain ∼ 60% of the numbe...

The clinical outcome of anti-infective treatment is determined by both PK and PD properties of the antibiotic. Only the free tissue concentrations of antibiotics at the target site, which are usually lower than the total plasma concentrations, are responsible for therapeutic effect. The free antibiotic concentrations at the site of action are a more appropriate PK input value for PK-PD analysis...

The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related to the prolonged achlorhydria produced by this potent unsurmountable histamine...

more detailed explanation of the basis for MCIA's position. Woodruff et al. (1) incorrectly suggest that industrial air emissions of methyl chloride present a significant health risk. On the basis of 1990 data for the Toxics Release Inventory (TRI) and the Cumulative Exposure Project (CEP), Woofruff et al. purport to identify listed hazardous air pollutants (HAPs) that are present in the enviro...

The fundamental topic in this document is the development of cracks in steel. For structures subjected to cyclic loads, such cracks can develop over time and ultimately reach the size at which some dramatic failure occur. While this problem is rare in structures made of “mild steel,” the use of “high tensile” steel changes that situation. It is straightforward to double the strength of mild ste...

The concentrations of cefepime in pancreatic pseudocyst fluid (n = 4), pancreatic tissue (n = 4) and pancreatic fistula fluid (n = 1), and simultaneous plasma concentrations, were measured after intravenous administration of a single 2 g dose to nine patients. Mean plasma concentration was 27.4 mg/L between 120 and 200 min after the end of infusion. Mean pancreatic cefepime concentration was 6....

Plasma thyroid hormone concentrations may be abnormal in non-thyroid disease and pose diagnostic problems. For example, concentrations of triiodothyronine (T3) in the blood decline in acute illness with a reciprocal increase in reverse triiodothyronine (reverse T3), but thyroxine (T4) concentrations are usually normal or only slightly decreased (1, 2). However, McLarty et al. (3) reported that ...

Urinary selenium concentrations are used as an indicator of selenium status. A strong correlation has been established between dietary selenium and daily urinary selenium excretion in a wide range of populations from all over the world with different dietary selenium intake. Data on urinary selenium concentrations in healthy individuals and patients with different pathological conditions are re...