The neutralizing antibody content for poliomyelitis virus has been tested with both a human and a passage strain of the virus in serial samples of sera from five mild cases of abortive poliomyelitis, and an increase in this antibody content has been demonstrated in convalescent samples obtained within 4 weeks of the acute illness.

Qualitative immunological differences exist between early passage strains or so called human strains of the virus of poliomyelitis. These differences show a relationship to the epidemic source of the virus and are exemplified in this study by 4 strains isolated in different years during an eastern and western epidemic of poliomyelitis.

BACKGROUND Pakistan and Afghanistan are two of the three remaining countries yet to interrupt wild-type poliovirus transmission. The increasing incidence of poliomyelitis in these countries during 2010-11 led the Executive Board of WHO in January, 2012, to declare polio eradication a "programmatic emergency for global public health". We aimed to establish why incidence is rising in these countr...

1. By means of a single large dose of poliomyelitis virus, distributed at a number of intradermal sites, active immunity has been produced in Macacus rhesus monkeys, as shown by skin neutralization and intracisternal tests. 2. In the small series (four animals) of monkeys so treated, neither abortive nor paralytic signs of experimental poliomyelitis appeared.

In two series of the experiments here recorded the monkey which had been repeatedly exposed to x-rays responded with typical acute poliomyelitis to an intracerebral inoculation of poliomyelitic virus filtrate, whereas the normal control receiving the same dose showed no symptoms. In another series the x-rayed animal came down with typical poliomyelitis after inoculation with three-fourths of th...

Lethargic encephalitis is an epidemic disease, the main manifestations of which relate to injury inflicted upon the central nervous system and in particular the basal ganglia of the brain. Poliomyelitis is an epidemic disease, the main manifestations of which relate to injury inflicted upon the central nervous system and in particular the gray matter of the spinal cord and medulla oblongata. At...

STUDY OBJECTIVES To assess the amount of poliomyelitis and its epidemiological features including risk factors. DESIGN This was a retrospective study of cases of paralytic poliomyelitis among children 0-6 years of age. SETTING Pondicherry, India, 1983-89. SUBJECTS A total of 47,960 children aged less than 6 years. MEASUREMENTS AND MAIN RESULTS In 1989, 469 field workers undertook a door...

Quantitative neutralization tests in monkeys were carried out on sera obtained from 7 patients, 3 months, and 3 years after an attack of poliomyelitis. The serum specimens were tested against 100 to 1000 PD(50) of the patient's own strain of virus, recovered during the acute phase of the illness; all the strains were Type 1. The 6 patients, aged 6 months to 13 years, who had a paralytic attack ...

The cover design is based on a 3000 year old Egyptian hieroglyph depicting a Syrian boy named Ruma, who at 5 years old got very sick with pain in his head and his leg ached. His father carried the boy to the temple where they believed the priest would cure him with powerful magic. The story of Ruma is perhaps the earliest pictorial record of Polio. The stone tablet (stele) tells the story of Ru...