We have previously demonstrated that injections of the thrombin-related peptide, TP508, into the lengthening gap have significantly enhanced bone consolidation in a rabbit model of distraction osteogenesis. This study was to further test the effect of a single TP508 injection in slow release preparation on bone formation during distraction osteogenesis. Rabbits had left tibiae lengthened unilat...

The function of a photocrosslinked poly(propylene fumarate) (PPF)/poly(N-vinyl pyrrolidone) (PVP) matrix for the sustained release of three ophthalmic model drugs, acetazolamide (AZ), dichlorphenamide (DP), and timolol maleate (TM), was investigated. The drugs differ in molecular weight and degree of dissociation in aqueous environments; both are parameters that significantly influence drug dif...

The MesoDyn method is used to investigate associative structures in aqueous solution of a nonionic triblock copolymer consisting of poly(propylene oxide) capped on both ends with poly(ethylene oxide) chains. The effect of adsorbing (hydrophobic) and nonadsorbing (hydrophilic) solid surfaces in contact with aqueous solutions of the polymer is elucidated. The macromolecules form self-assembled st...

Triblock, diblock and random copolymers of poly(ethylene oxide) and poly(propylene oxide) are used as molecular templates in poly(methyl silsesquioxane) (MSQ) matrices to fabricate ultra low-k dielectric materials (kp2:0). Solidstate NMR shows that polymer architecture plays an important role in the polymer domain size and the polymer– matrix interface in the nanocomposites. Positronium annihil...

The (salen)Co(III) complex 1 tethering four quaternary ammonium salts, which is a highly active catalyst in CO2/epoxide copolymerizations, shows high activity for propylene oxide/phthalic anhydride (PO/PA) copolymerizations and PO/CO2/PA terpolymerizations. In the PO/PA copolymerizations, full conversion of PA was achieved within 5 h, and strictly alternating copolymers of poly(1,2-propylene ph...

A novel dendritic star-copolymer, generation 3 poly(propylene thiophenoimine) (G3PPT)-co-poly(3-hexylthiophene) (P3HT) star co-polymer on gold electrode (i.e., Au|G3PPT-co-P3HT) was used as a sensor system for the determination of phenanthrene (PHE). The G3PPT-co-P3HT star co-polymer was synthesized via in situ electrochemical co-polymerization of generation 3 poly (propylene thiophenoimine) an...

The objective of this study was to design lipopolymers for hydrophobic drug delivery. Poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (PEG-PCD) lipopolymers were synthesized and characterized by (1)H NMR, FT-IR, GPC, and DSC. The critical micelle concentration (CMC) of PEG-PCD micelles was around 10(-8) M and decreased with increasing length of hydropho...

A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.

This study describes the first example of the investigation of electronic, geometric, and catalytic properties of Pd subnano metal clusters of Pd(4), Pd(8), and Pd(16) stabilized by poly(propylene imine) (PPI) dendrimers using XAFS and IR analyses. The relations among these properties are also discussed.