BACKGROUND Gene transfer using a nanoparticle vector is a promising new approach for the safe delivery of therapeutic genes in human disease. The Tat peptide-decorated gelatin-siloxane (Tat-GS) nanoparticle has been demonstrated to be biocompatible as a vector, and to have enhanced gene transfection efficiency compared with the commercial reagent. This study investigated whether intracisternal ...

We present a study of a range of cross-linked chitosan composites with potential antimicrobial applications. They were formed by cross-linking chitosan and siloxane networks and by introducing silver and gold nanoparticles (NPs). The aim was to investigate whether adding the metal NPs to the chitosan-siloxane composite would lead to a material with enhanced antimicrobial ability as compared to ...

This paper deals with low-temperature mineralisation of coatings made titania-siloxane compositions (TSC). Methyltriethoxysilane has been adopted as the precursor for siloxane, and during its synthesis, an oligomeric siloxane condensate methyl moieties acting TiO2 binder produced. These moieties, contained in TSC, provide solubility prevent gelling, but reduce hydrophilicity system, transfer el...

Background Controlled drug delivery system is highly important for not only prolonged the efficacy of drug but also cellular development for tissue engineering. A number of biopolymer composites and nanostructured carriers behave been used for the controlled drug delivery of therapeutics. Recently, in vitro microfluidic devices that mimic the human body have been developed for drug-delivery app...

Cyclopentadienyl (Cp)-coordinated cationic Si(II) (1) and Ge(II) compounds (2) are a new class of catalysts for various transformations in organosilicon chemistry. This review demonstrates that these effectively catalyze technically important reactions, such as the hydrosilylation carbon-carbon multiple bonds types siloxane-coupling e.g., Piers-Rubinsztajn reaction oxidative siloxane coupling r...

Pure gas permeability coefficients of a series of copolymers based on polar, hydrophilic poly(ethylene glycol) dimethacrylate, n 1⁄4 14 (PEGDMA) and siloxane-based co-monomer, [methyl bis(trimethylsiloxy) silyl] propyl glycerol methacrylate (SiGMA) are reported. SiGMA is miscible with PEGDMA and able to form homogeneous films. SiGMA contains a bulky siloxane-based end group, which acts to incre...