1 Max-Planck-Institut für Polymerforschung, D-55021 Mainz, Postfach 3148, FRG Institute of Physical Chemistry PAS and College of Sciences Dept. III, Kasprzaka 44/52, 01224 Warsaw, Poland Abstract We apply density functional theory to study the influence of polydispersity on the stability of columnar, smectic and solid ordering in the solutions of rodlike macromolecules. For sufficiently large l...

By means of extensive contact dynamics simulations, we analyze the combined effects of polydispersity both in particle size and in particle shape, defined as the degree of shape irregularity, on the shear strength and microstructure of sheared granular materials composed of pentagonal particles. We find that the shear strength is independent of the size span, but unexpectedly, it declines with ...

Chitosan (CS)-modified poly(d,l-lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) were prepared and their lung targetability after intravenous administration was elucidated. PLGA NPs (mean diameter: 225nm; polydispersity index: 0.11; zeta potential: -15mV), 0.2% (w/v) CS-coated PLGA NPs (CS02-PLGA NPs, mean diameter: 264nm; polydispersity index: 0.17; zeta potential: -7mV), and 0.5% (w/v) CS-...

The aim of present study was to formulate and evaluate nanoparticles of acyclovir by using different hydrophilic polymers. Acyclovir was selected as a suitable drug for gastroretentive nanoparticles due to its short half life, low bioavailability, high frequency of administration, and narrow absorption window in stomach and upper part of GIT. The nano-precipitation method was used to prepare na...

We dynamically simulate fractionation (partitioning of particle species) during spinodal gas-liquid separation of a size-polydisperse colloid, using polydispersity up to ~40% and a skewed parent size distribution. We introduce a novel coarse-grained Voronoi method to minimise size bias in measuring local volume fraction, along with a variety of spatial correlation functions which detect fractio...

BACKGROUND AND AIMS Quercetin is a flavonoid with good antioxidant activity, and exhibits various important pharmacological effects. The aim of the present work was to study the influence of formulation factors on the physicochemical properties of quercetin-loaded polymeric nanoparticles in order to optimize the formulation. MATERIALS AND METHODS The nanoparticles were prepared by the nanopre...