A hydroxypropyl methylcellulose (HPMC K4M, HPMC K15M, and HPMC K100M) matrix tablet containing Indomethacin along with mannitol was formulated as a function of HPMC viscosity, and was compared with the commercial products. The release characteristics of the matrix tablet were investigated in the intestinal fluid, 6.8 pH phosphate buffer for 12 hours. The formulated products and two marketed pro...

Thermal spray has traditionally been used for depositing metallic, carbide and ceramic coatings, however, it has recently been found that the high kinetic energy of the High Velocity Oxy-Fuel (HVOF) thermal spray process also enables the solventless processing of high melt viscosity polymers, eliminating the need for harmful, volatile organic solvents. A primarily goal of this work was to devel...

Floating matrix tablets of losartan potassium were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, usin...

We undertake the investigation of sheared polymer chains grafted onto flat surfaces to model liposomes covered with polyethylene glycol brushes as a case study for the mechanisms of efficient drug delivery in biologically relevant situations, for example, as carriers for topical treatments of illnesses in the human vasculature. For these applications, specific rheological properties are require...

It is well-known that an irreversible decrease in serum viscosity occurs when tomato juice is concentrated by evaporation into paste. Several studies have suggested that the loss in serum viscosity is due to pectin depolymerization, caused by the high temperatures used during industrial tomato paste production. This study demonstrates that conformational changes in pectin may play a more import...

Knowledge of the structure and interactions of mixed polymer/surfactant colloidal systems is essential for simultaneously controlling the stability and rheological properties of colloidal dispersions such as emulsions and lubricating oils [1, 2]. The surfactant and polymer together provide stability against coagulation and control the viscosity of the ̄uid, the practical aim being to produce hig...

Different polymer formulations possess unique chemical, physical, and mechanical properties. Small variations in the structure of a given polymer formulation can significantly change its characteristics, resulting in new functions and applications. For example, polyvinyl alcohol is a water-soluble synthetic polymer made by alcoholysis of polyvinyl acetate. Its chemical and physical properties d...

The diffusion coefficient D of bovine serum albumin through various solutions (pH 7.0, 0.5M NaCl) of polyethylene oxide ( M , 1 x lo5, 3 x lo5) was studied with quasielastic light scattering. In solutions of the 1 x lo5 polymer solution a t polymer concentrations above 0.5 g/L, D is considerably greater than would have been expected from the viscosity of water:polymer mixtures, the deviations b...

Polystyrene grafted with acrylonitrile using gamma-irradiation technique was successfully synthesized. This process was carried out at various gamma dose (0.2-1.5 Mrad). The new grafted polymer was characterized and its properties were investigated. The results indicate that best grafting percentage ratio could be revealed when the concentration of the catalyst Ferrous Ammonium Sulphate (FAS) i...