Normal rat liver cytosol was found previously to contain a 14,000-dalton polypeptide that is the principal target of the carcinogen N-2-fluorenylacetamide (2-acetyl-aminofluorene) early during hepatocarcinogenesis. By using antiserum that identifies the 14,000-dalton polypeptide in liver cytosol, an immunologically related 17,500-dalton polypeptide was shown to be present in isolated normal liv...

Studies on ultrafiltrates of the plasma of normal and diabetic subjects have shown that a polypeptide of similar characteristics to the growth-hormone-derived polypeptide In-G is present in higher concentrations in diabetic subjects, thus indicating a possible role in the pathogenesis of diabetes mellitus. The polypeptide is absent from the plasma of hypophysectomized diabetic patients.

weight; CCKcholecystokinin; CCK1 and CCK2 receptors for gut peptides (CCK and/or gastrin) of type 1 (or A) and type 2 (or B), respectively; GI gastrointestinal; GIT gastrointestinal tract; GRP gut regulatory peptide; EU European Union; HSP heat shock protein; PACAP pituitary adenylate cyclaseactivating polypeptide; PP pancreatic polypeptide; PRPs proline-rich proteins; SI small intestine; VIP v...