The objective of this study was focussed on phytochemical screening, in vitro antioxidant and antiprotease activities various solvent extracts Muehlenbeckia platyclada root. roots were washed thoroughly, shade dried coarsely powdered. powdered material successively extracted with hexane, chloroform methanol using soxhlet apparatus. Preliminary screening for carbohydrates, proteins, alkaloids, p...

BACKGROUND Ten genotypes representing two elderberry species, Sambucus canadensis L. (eight genotypes) and S. nigra L. (two genotypes), were examined for their anthocyanins (ACY), total phenolics (TP),°Brix, titratable acidity (TA), and pH over two growing seasons. RESULTS Overall, fruit generally had higher ACY, TP, ACY/TP,°Brix, and pH in 2005 than 2004. All samples of S. canadensis had sim...

Possible anticancer mechanisms exerted by polyphenolic compounds contained in fruits and vegetables include antioxidant activity, the inhibition of proliferation, and the induction of apoptosis in cancer cells. This study examined the effects of four isolated polyphenolic extracts from red muscadine grapes (Vitis rotundifolia) on vital cell parameters and the induction of apoptosis in Caco-2 co...

Antioxidants generally possess the ability to protect the body from damage caused by free radical induced oxidative stress and disorders. Polyphenolics, especially flavonoids from plants serve as a good source of antioxidants. Investigation on the efficiency of these phenolics is of interest during recent years. The purpose of this work is to determine the total phenolic content, total flavonoi...

The facility and versatility of microRNAs (miRNAs) to evolve and change likely underlies how they have become dominant constituents of eukaryotic genomes. In this opinion article I propose that trans-acting small interfering RNA gene 4 (TAS4) evolution may be important for biosynthesis of polyphenolics, arbuscular symbiosis, and bacterial pathogen etiologies. Expression-based and phylogenetic e...

Air dried flowers of Nerium oleander and Tecoma stans have been investigated for their polyphenolics. The pigments have been found to myricetin and rutin respectively which were characterized by chromatography and spectral studies. These pigments were screened for their antibacterial and antifungal activity against different organisms. It was ascertained that the ethyl acetate fractions of flow...

Polyphenolics are a large group of related substances. Many of these, in fact much of that found in food, is composed of processing-derived substances too complex for complete identification. Recent studies have suggested likely benefits for diets high in polyphenols, particular in reducing heart disease mortality, but other benefits have also been suggested. A consumer label based on the major...

The protein deacetylase SIRT1 is involved in the regulation of a large number of cellular processes that are thought to be required for cancer initiation and progression. Both SIRT1 activity and tumorigenesis can be influenced by dietary fat and polyphenolics. We set out to determine whether dietary modulations of tumorigenesis are mediated by SIRT1 catalytic functions. We introduced a mammary ...

Bottle gourd [(Lagenaria siceraria (Mol.) Stand.] fruit is ascribed with many therapeutic effects. The present study was undertaken to explore the antihyperlipidemic effect of four different extracts viz. petroleum ether, chloroform, alcoholic and aqueous extracts from bottle gourd in Triton-induced hyperlipidemic rats and their hypolipidemic effects in normocholesteremic rats. The study is com...