The possible use of liposomes as topical drug delivery vehicles for both water- and lipid-soluble drugs has been investigated. Data for two characteristic drugs, penicillin G and indoxole, are presented. Liposome uptake by the cornea is greatest for positively charged liposomes, less for negatively charged liposomes, and least for neutral liposomes, suggesting that the initial interaction betwe...

I. The interfacial barrier controlled transport of some biologically important solutes in the aqueous polysorbate 8o-hexadecane system were investigated by means of the multiparticulate dispersion technique. 2. It was shown that the resistances to transport of cholesterol, /5-sitosterol, desmosterol, 2o~-hydroxycholesterol, and vitamin D~ across the oil/water interface, were of the order of lO3...

BACKGROUND The epithelial cell adhesion molecule (EpCAM) embedded in the plasma membrane of circulating epithelial tumor cells (CETC) is used for detection and enrichment of circulating tumor cells in peripheral blood and as a target for anti-epithelial antibodies elicited during immune response in anti-tumor immunization. Although an efficient immune response against EpCAM can be generated, th...

DNA-complexes with platelet-like, cationically modified lipid nanoparticles (cLNPs) are studied with regard to the formation of nanocomposite structures with a sandwich-like arrangement of the DNA and platelets. For this purpose suspensions of platelet-like triglyceride nanocrystals, stabilized by a mixture of two nonionic (lecithin plus polysorbate 80 or poloxamer 188) and one cationic stabili...

This work describes the formulation design and development of a novel protein based adjuvant, a double mutant of heat labile toxin (dmLT), based on knowledge of the protein's structural integrity and physicochemical degradation pathways. Various classes of pharmaceutical excipients were screened for their stabilizing effect on dmLT during exposure to thermal and agitation stresses as monitored ...

this study was carried out to investigate the effect ofadministration of satureja khuzistanica essential oil (skeo) in drinking water on performance, lipid oxidation, activity of antioxidative enzymes and cholesterol content of thigh meat using 720 one-day-old ross 308 broiler chicks. the skeo was added into drinking water at zero (control-), 200, 300, 400 and 500 mg/l along with a treatment co...

New analytical methods have been developed and validated on high performance liquid chromatography (HPLC) to assess the assay, content uniformity and dissolution of immediate release candesartan cilexetil 32 mg tablets. Method development studies were performed on cyano column. Mobile phase of assay and content uniformity test consisted of mixture of 0.05 M phosphate buffer, pH 4.5 and methanol...