BACKGROUND DNA vaccination has been shown to elicit specific cellular and humoral immune responses to many different agents in a broad variety of species. However, looking at a commercial use, the duration of the immune response against the vaccine is critical. Therefore the persistence of the DNA vaccine, as well as its expression, should be investigated. We conducted these investigations on a...

polytope Abstract polytope November, 2013 – p. 2 Abstract polytope Abstract polytope −→ combinatorial generalization of convex polytopepolytope Abstract polytope −→ combinatorial generalization of convex polytope November, 2013 – p. 2 Abstract polytope Abstract polytope −→ combinatorial generalization of convex polytopepolytope Abstract polytope −→ combinatorial generalization of convex polytop...

BACKGROUND A DNA vaccine encoding the whole segment of the Derp2 allergen could prevent allergic airway inflammation in a Derp2 allergen-induced allergic airway inflammation mouse model. OBJECTIVE This study investigated the effect of DNA vaccine encoding Derp2-mutant gene in which an IgE epitope was deleted on airway inflammation and the role of TLR9 in the asthmatic mouse model. METHODS A...

BACKGROUND Tyrosine kinase inhibitor gefitinib is effective against lung cancer cells carrying mutant epidermal growth factor receptor (EGFR); however, it is not effective against lung cancer carrying normal EGFR. The breaking of immune tolerance against self epidermal growth factor receptor with active immunization may be a useful approach for the treatment of EGFR-positive lung tumors. Xenoge...

Background: Hepatitis C virus (HCV) infection is one of the most prevalent infectious diseases responsible for high morbidity and mortality worldwide. Therefore, designing new and effective therapeutics is of great importance. The aim of the current study was to construct a DNA vaccine containing structural proteins of HCV and evaluation of its expression in a eukaryot...

background: studies on efficacy of various vaccines that prevent or reduce the primary and recurrent hsv-1 infection have demonstrated the importance of cellular immunity for protection against the infection. we previously used dna vaccination to induce cellular immunity against hsv-1 infection in mice. objective: the aim of our study was to evaluate the effect of light, a member of tnf super f...

An object representation scheme which allow_ fast Eucltdea,7 distance cal,:vlatu_rz is prese_ted. The object model eztends the polytope model by representLny objects as the convez hull of a finite set of spheres. An algorithm for calculating distances between objects is developed which is linear in the total number of spheres specifying the two objects.

We prove that the ranks of the subsets and the activities of the bases of a matroid define valuations for the subdivisions of a matroid polytope into smaller matroid polytopes.