It is thought that the topology of a polytopic protein is generated by sequential translocation and membrane integration of independent signal-anchor and stop-transfer sequences. Two well-characterized cell-free systems (rabbit reticulocyte lysate and wheat germ extract) have been widely used to study the biogenesis of secretory and membrane proteins, but different results have been observed wi...

This paper addresses the problem of designing control systems for steering an autonomous vehicle, varying speed, ensuring stability and sustaining performance, taking into account comfort safety. A novel automatic lateral architecture is proposed combining Linear Parameter Varying (LPV) theory Pure-Pursuit algorithm. The response robust controller investigated tracking a reference trajectory. i...

In this paper, we propose a learning-based Model Predictive Control (MPC) approach for the polytopic Linear Parameter-Varying (LPV) systems with inexact scheduling parameters (as exogenous signals bounds), where Time Invariant (LTI) models (vertices) captured by combinations of becomes wrong. We first to adopt Moving Horizon Estimation (MHE) scheme simultaneously estimate convex combination vec...

Discontinuous Galerkin (dG) methods on meshes consisting of polygonal/polyhedral (henceforth, collectively termed as polytopic) elements have received considerable attention in recent years. Due to the physical frame basis functions used typically and quadrature challenges involved, matrix-assembly step for these is often computationally cumbersome. To address this important practical issue, wo...

Soluble proteins often contain multiple structural domains, which are shuffled or recombined to gain new functions in the course of evolution. We examined integral membrane proteins for evidence of this mechanism using a classification of polytopic transmembrane domains. Surprisingly, in contrast to the situation in aqueous solution, we found that recombination of structural domains is not comm...

Endoplasmic reticulum-associated degradation (ERAD) plays a critical role in the destruction of terminally misfolded proteins at the secretory pathway. The system also regulates expression levels of several proteins such as Pca1p, a cadmium exporter in yeast. To gain better insight into the mechanisms underlying ERAD of Pca1p and other polytopic proteins by the proteasome in the cytosol, our st...

This paper investigates the stability properties of a class of dynamic linear systems possessing several linear time-invariant parameterizations or configurations which conform a linear timevarying polytopic dynamic system with a finite number of time-varying time-differentiable point delays. The parameterizations may be timevarying and with bounded discontinuities and they can be subject to mi...