Structured abstract Question: In patients undergoing surgery, does prophylactic dimenhydrinate reduce the frequency of postoperative nausea and vomiting (PONV) compared to placebo? Data sources: Studies were identified by computerized searches (MEDLINE, EMBASE, Cochrane Library) up to June 2001, citation review, and hand searches of locally available anesthesia journals. No language restriction...

BACKGROUND Postoperative nausea and vomiting (PONV) is one of common complications in patients undergoing laparoscopic cholecystectomy (LC). Aim of this study was to compare the efficacy of subhypnotic (1 mg/kg/h) infusion of propofol with dexamethasone on PONV in patients undergoing LC. METHODS A total of 120 patients were included in this randomized, double-blind, placebo-controlled study. ...

OBJECTIVE To provide recommendations for the management of postoperative nausea and vomiting (PONV), which may affect as many as 30% of patients. METHODS AND EVIDENCE: Medline, PubMed, and the Cochrane Database were searched for articles published in English from 1995 to 2007. Recognizing that we must work as a team to optimize the care of our patients perioperatively, this guideline was writte...

In this randomized study we compared the efficacy of ondansetron 4 mg with ondansetron 8 mg for the prevention of postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy with sevoflurane and remifentanil infusion anaesthesia. Sixty patients were randomized to receive ondansetron 8 mg (30 pts) or ondansetron 4 mg (30 pts) before the induction of anaesthesia with thiopental an...

Objective This study was designed to compare the effectiveness of granisetron plus dexamethasone for preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic surgery. Methods We searched the literature in the Cochrane Library, PubMed, EMBASE, and CNKI. Results In total, 11 randomized controlled trials were enrolled in this analysis. The meta-analysis showed that g...

POSTOPERATIVE NAUSEA AND VOMITING (PONV) remains one of the most common, and most distressing postoperative complications. Despite advances in pharmacological and nonpharmacological prophylactic and rescue interventions, postoperative vomiting (POV) occurs in approximately 30% of surgical patients, while the incidence of nausea is around 50%. The incidence of PONV in high risk patients may run ...

PURPOSE To compare the use of promethazine 6.25 mg intravenous (IV) (experimental group) with promethazine 12.5 mg IV (control group) among adult ambulatory surgery patients to control established postoperative nausea or vomiting (PONV). DESIGN/METHODS In a double-blind, randomized controlled trial (n = 120), 59 subjects received promethazine 6.25 mg and 61 subjects received promethazine 12.5...

BACKGROUND During a previous study to define and compare incidence risks of postoperative nausea and vomiting (PONV) for elective laparoscopic and open cholecystectomy at two hospitals in Jamaica, secondary analysis comparing PONV risk in elective open cholecystectomy to that after emergency open cholecystectomy suggested that it was markedly reduced in the latter group. The decision was made t...