In this study, in situ strength of concrete was determined through compression test of cores drilled out from laboratory cast beams. The apparent porosity and pore size distribution of the same concrete were determined through mercury intrusion porosimetry, performed on small-drilled cores. The normal-strength concrete mixes used in the experimental investigation were designed to exhibit a wide...

In CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, ATP-binding-induced dimerization of two cytosolic nucleotide binding domains (NBDs) opens the pore, and dimer disruption following ATP hydrolysis closes it. Spontaneous openings without ATP are rare in wild-type CFTR, but in certain CF mutants constitute the only gating mechanism, stimulated by ivacaftor, a clinically appro...

soilless media have different physical properties. change in air space of mix substrate can cause change in fertigation management and plant growth and yield. physical properties (water holding capacity, effective air-filled pore space, effective pore space) of 50 mixed substrates were measured to evaluate the effect of air-filled pore space on growth of tomato transplant and it's water us...

Kvbeta subunits are accessory proteins that modify gating of Kv1 channels. Kvbeta1.3 subunits bind to the N termini of Kv1.5 alpha-subunits and induce fast N-type inactivation, slow the rate of deactivation, and alter the voltage dependence and kinetics of channel activation. The N terminus of a Kvbeta subunit and quaternary ammonium compounds bind to the inner pore of Kv1 channels; however, it...

Inactivation is the process by which an open channel enters a stable nonconducting conformation after a depolarizing change in membrane potential. Inactivation is a widespread property of many different types of voltage-gated ion channels. Recent advances in the molecular biology of K+ channels have elucidated two mechanistically distinct types of inactivation, N-type and C-type. N-type inactiv...

Lotus-type porous aluminum with cylindrical pores oriented in one direction was fabricated by a casting method utilizing the decomposition of moisture in a vacuum. Hydrogen decomposed from moisture is utilized for cylindrical pores to grow during unidirectional solidification. However, pores are not formed in the case of a casting in hydrogen or argon atmosphere, because hydrogen or argon gas p...

Pore-blocking toxins inhibit voltage-dependent K(+) channels (Kv channels) by plugging the ion-conduction pathway. We have solved the crystal structure of paddle chimera, a Kv channel in complex with charybdotoxin (CTX), a pore-blocking toxin. The toxin binds to the extracellular pore entryway without producing discernable alteration of the selectivity filter structure and is oriented to projec...

constant rate of strain (crs) consolidation is a rapid test method used for determination of compressibility of clayey soils. in a crs test, the appropriate strain rate is selected based on pore water pressure ratio, i.e. the ratio of pore pressure to total stress. in the present study, to investigate the effect of strain rate on variation of relative pore water pressure, four different clay sa...

The herpes simplex virus ICP27 protein is important for the expression and nuclear export of viral mRNAs. Although several binding sites have been mapped along the ICP27 sequence for various RNA and protein partners, including the transport receptor TAP of the host cell nuclear transport machinery, several aspects of ICP27 trafficking through the nuclear pore complex remain unclear. We investig...

Novel mesoporous BN and BCN materials with cage type porous structure and spherical morphology have been synthesized using carbon nanocages with 3D porous structure as a template via an elemental substitution method at a low synthesis temperature. The obtained materials exhibit a large specific pore volume with uniform pore size distribution and the specific surface area ranging from 945 to 102...