Previous studies have shown that pretreatment of E. coli with low doses of kanamycin have generated an increase in the resistance to high doses of kanamycin as well as induced cross resistance to a broad range of unrelated antibiotics, and that multiantibiotic-resistant E. coli had lower levels of OmpF porin. In this study, the role of OmpC and OmpF porins in the development of cross resistance...

Eukaryotic porins are a group of membrane proteins whose best known role is to form an aqueous pore channel in the mitochondrial outer membrane. As opposed to the bacterial porins (a large family of protein whose 3D structure has been determined by X-ray diffraction), the structure of eukaryotic porins (also termed VDACs, voltage-dependent anion-selective channels) is still a matter of debate. ...

The OprD family of specific porins in Pseudomonas aeruginosa comprises 19 members, some of which have been demonstrated to facilitate the uptake of specific compounds into the cell. The members of this family share considerable amino acid sequence similarity (46–57%), which is unusual among porin molecules. In this work, we sought to establish whether this sequence conservation was the basis fo...

Antibodies acquired after vaccination or natural infection with Gram-negative bacteria, such as invasive Salmonella enterica serovar Typhimurium, can protect against disease. Immunization with naturally shed outer membrane vesicles from Gram-negative bacteria is being studied for its potential to protect against many infections, since antigens within vesicles maintain their natural conformation...