We evaluated a novel truncated hygromycin A analog in which the furanose ring was replaced with a 2-fluoro-2-cyclopropylethyl substituent for its activity against multidrug resistant gram-positive bacteria and compared its activity to the activities of linezolid, quinupristin-dalfopristin, and vancomycin. CE-156811 demonstrated robust in vitro activity against gram-positive bacteria that was co...

Microbial contamination of water poses a major threat to public health. With the emergence of microorganisms resistant to multiple antimicrobial agents, there is increased request for promotion of disinfection methods. Since ultrasound wave (US) exhibits antibacterial activities on bacteria, the aim of this study was to evaluate the antimicrobial effect of low frequency (37 kHz) ultrasound on P...

background: despite the discovery of numerous antibiotics, drug resistance still remains as a major problem. therefore, it is important to introduce and replace new sources of drug such as medicinal plants with antimicrobial properties. objective: the genus clematis (ranunculaceae family) has six species in iran. aerial parts of clematis have been used to cure fever and chronic diseases such as...

The aim of the study was to assess the epidemiology, the incidence of multidrug-resistant bacteria and bloodstream infections' (BSIs) seasonality in a university hospital. This retrospective study was carried out in the University General Hospital of Patras, Greece, during 2011-13 y. Blood cultures from patients with clinical presentation suggestive of bloodstream infection were performed by th...

Objective(s): The use of new technologies, which can be realized as nanotechnology, is a novel approach in this sector. Covers made of silver nanoparticles effectively prevent and reduce invasion of microorganisms, compared with other conventional covers. This study was conducted to determine the effects of nanosilver covers in comparison with other conventional covers. <stron...

the antimicrobial activity of thirty six novel dihydropyrimidine derivatives was evaluated against common pathogenic bacteria. significant antimicrobial activity (mic=32, 64 µg/ml) was observed. escherichia coli and pseudomonas aeruginosa as gram-negative bacteria and staphylococcus aureus as gram-positive bacteria were determined to be the most susceptible pathogens in this study. the highest ...

Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.

BACKGROUND Bacteria are suspected players in the pathogenesis of chronic rhinosinusitis (CRS), yet their exact role is not understood. We investigated the effect of planktonic and biofilm of staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) on the mucosa of CRS patients with gram-positive and gram-negative infections by measuring the levels of IL-6 and RANTES, a chemokine with activity...