Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates a...

EXPRESSION OF CD33 ANTIGEN ON NORMAL HUMAN ACTIVATED T LYMPHOCYTES To the Editor. granulocytes in vivo. However, it has not been detected on eryCD33 antigen (glycoprotein M, 67,000). detected by the monoWe successfully detected the expressions of CD33 antigen on norclonal antibodies (MoAbs) MY-9 and Leu-M9, is in highest conmal human peripheral CD4+ T and CD8' T lymphocytes that were centratio...

Generating a large population of memory CD8 T cells is an appealing goal for vaccine design against a variety of human diseases. Indeed, experimental models have demonstrated that the overall number of memory CD8 T cells present at the time of infection correlates strongly with the ability to confer host protection against a range of different pathogens. Currently, the most conceivable approach...

Human Mast Cells Modulate Proliferation and Cytokine Production by CD8+ T Lymphocytes F.L. Francina L. de Pater-Huijsen M.J. Mariëlle J. de Riemer R.M.R. Richard M.R. Reijneke M. Marjolein Pompen R. René Lutter H.M. Henk M. Jansen T.A. Theo A. Out Department of Pulmonology, Clinical and Laboratory Immunology Unit, Academic Medical Center and Laboratory for Experimental and Clinical Immunology (...

Recent preclinical and clinical trials have demonstrated the therapeutic potential of T lymphocytes redirected with genetically engineered T-cell receptor (TCR) surrogates against infected, cancerous, or autoreactive cells. These surrogate TCRs link a ligand-recognition domain to signaling regions from the TCR. We previously compared the function of surrogate TCRs that include TCR or TCR and CD...

T lymphocytes bearing the gamma/delta T cell receptor (TCR-gamma/delta) express a limited number of germline variable gene segments, generating receptor sequence diversity primarily through junctional mechanisms. To examine the role of V(D)J junctional sequences in antigen recognition by TCR-gamma/delta, we derived an alloreactive murine TCR-gamma/delta+ T cell line, LKD1, specific for the I-Ad...

The responsiveness of purified Fc- and Fc+ T lymphocytes, isolated from normal spleen cell populations by cell sorting on the fluorescence activated cell sorter, has been examined. Although both Fc- and Fc+ T cells responded to phytohemagglutinin, the response to concanavalin A (Con A) was found to be a characteristic of the Fc+ T lymphocyte. The poor responsiveness of the Fc- T cells to Con A ...