Recurrent meningitis is an uncommon clinical problem which results from post-traumatic osteomeningeal defect. Streptococcus pneumoniae accounts for 80% of central nervous system infections associated with bony anatomical defects in the skull. Despite vigorous use of antibiotics and aggressive supportive care, about 50% survivors have disabling neurological sequelae. Pneumococcal meningitis is a...

Abstract Purpose Measurements of cerebrospinal fluid (CSF) lactate can aid in detecting infections the central nervous system and surrounding structures. Neurosurgical patients with temporary lumbar or ventricular CSF drainage harbor an increased risk for developing system, which require immediate therapeutic responses. Since blood gas analyzers enable rapid blood-lactate measurements, we were ...

Purpose: Hydrocephalus, abnormal accumulation of CSF in the ventricles, is one most common diseases brain. Ventriculoperitoneal shunting commonest procedures for management hydrocephalus. Assessment and evaluation clinical outcome, following VP shunt, should be carried out to decrease rates complications this procedure. Clinical audit plays a vital role identifying developing effective methods ...

Abstract Background CRAB continues to threaten the healthcare facilities in developing nations and is one among commonest causes of hospital acquired infections our hospital. In December 2021, IDSA published AMR guidance 2.0, that stated Ampicillin- sulbactam as first choice for treating infections. We review clinical outcomes with adherence this guideline setting. Methods A descriptive study f...

There is an increasing attention paid for nucleoside metabolism and changes of nucleoside concentrations in human brain because of its pathological and physiological relevance. In order to determine the post mortem degradation of nucleosides and nucleoside metabolites, the concentrations of four nucleosides and three nucleobases were measured in rat and neurosurgical human cerebral cortical sam...

The unequal distribution of neurosurgical resources and diseases in the world contributes to inequality. Eight in ten neurosurgical cases needing essential neurosurgical care are found in low- and middle-income countries (LMICs); however, LMICs lack the neurosurgical resources to address these needs. Besides, where neurosurgical care is available, it is not financially accessible to the majorit...

OBJECTIVE To assess the impact of the Haemophilus influenzae b (Hib) conjugate vaccine in reducing the incidence of meningitis among children under five years old. METHODS A 'before-after' design was used to compare Hib meningitis incidence rates in the pre-vaccine (July 1995 - June 1999) and post-vaccine (July 1999 - June 2001) periods in the state of Goias, central Brazil. Bacterial meningi...

OBJECTIVE This review describes the current concept of pneumococcal meningitis in cochlear implant recipients based on recent laboratory studies. It examines possible routes of Streptococcus pneumoniae infection to the meninges in cochlear implant recipients. It also provides insights into fundamental questions concerning the pathophysiology of pneumococcal meningitis in implant recipients. D...

INTRODUCTION Aqueductal stenosis is the commonest cause of congenital hydrocephalus. The scope of this paper is to highlight the disease burden of hydrocephalus attributed to aqueductal stenosis which still remains unknown in our setting. METHODS In a descriptive cross-sectional study, 258 records of patients diagnosed with hydrocephalus were analyzed after ethical approval from Kenyatta Nati...