BACKGROUND AND PURPOSE It was recently reported that the prevalence of poststroke memory dysfunction might be higher than previously thought. Stroke may exist concomitantly with underlying Alzheimer's disease (AD), and so we determined whether post-stroke memory dysfunction indicates manifestation of underlying subclinical AD. METHODS Of 1201 patients in a prospective cognitive assessment dat...

BACKGROUND AND PURPOSE Sugar- and artificially-sweetened beverage intake have been linked to cardiometabolic risk factors, which increase the risk of cerebrovascular disease and dementia. We examined whether sugar- or artificially sweetened beverage consumption was associated with the prospective risks of incident stroke or dementia in the community-based Framingham Heart Study Offspring cohort...

OBJECTIVES To review the evidence for an association of white matter hyperintensities with risk of stroke, cognitive decline, dementia, and death. DESIGN Systematic review and meta-analysis. DATA SOURCES PubMed from 1966 to 23 November 2009. STUDY SELECTION Prospective longitudinal studies that used magnetic resonance imaging and assessed the impact of white matter hyperintensities on ris...

BACKGROUND AND PURPOSE The purpose of this study was to define predictors of poor outcome after a first-ever stroke. We studied risk factors and stroke severity at baseline in relationship to death, dependency, and stroke recurrence within a year after the event. METHODS The study included a community-based cohort of first-ever stroke patients. Subarachnoid hemorrhage was not included. All pa...

Background Post Stroke Cognitive Impairment (PSCI) is seen in 40-60% of patients with ischemic strokes. Response PSCI to structured cognitive rehabilitation not clearly understood. We evaluated baseline variables that predict response an eight-week non-pharmacological intervention among mild strokes and compared the responses acute stroke without chronic cerebrovascular disease (CVD). Method 13...

BACKGROUND AND PURPOSE Both dementia and stroke are major health problems in Chinese societies. Stroke is a frequent cause of dementia. Only a few studies have been published on poststroke dementia (PSDE), none of which has investigated a consecutive stroke cohort in Asian patient populations. The objective of this study was to examine the prevalence and clinical correlates of PSDE in Chinese s...

Cognitive decline after stroke is more common than stroke recurrence. Stroke doubles the risk of dementia and is a major contributor to vascular cognitive impairment and vascular dementia. Neuropathological studies in most cases of dementia in the elderly reveal a large load of vascular ischemic brain lesions mixed with a lesser contribution of neurodegenerative lesions of Alzheimer disease. No...

BACKGROUND A common complication after stroke is development of cognitive impairment and dementia. However, effective strategies for reducing the risk of developing these problems remain undefined. Potential strategies include intensive lowering of blood pressure (BP) and/or lipids. This paper summarises the baseline characteristics, statistical analysis plan and feasibility of a randomised con...

BACKGROUND/AIM Post-stroke cognitive impairment and dementia may be caused by pure vascular, pure degenerative or mixed disease. The relation between post-stroke cognitive impairment and the combination of vascular pathology and degenerative changes is less evaluated. We aimed to evaluate the associations between white matter lesions (WMLs) and patient performance 1 year after stroke on tests o...