BACKGROUND Diverse environmental contaminants, including the plasticizer di(2-ethylhexyl)phthalate (DEHP), are hepatocarcinogenic peroxisome proliferators in rodents. Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activation and its sequelae have been proposed to constitute a mode of action (MOA) for hepatocarcinogenesis by such agents as a sole causative factor. Further, based o...

Objective—We recently reported that the peroxisome proliferator-activated receptor (PPAR ) ligands 15-deoxyprostaglandin J2 (15d-PGJ2) and ciglitazone increased cultured endothelial cell nitric oxide (NO) release without increasing the expression of endothelial nitric oxide synthase (eNOS). The current study was designed to characterize further the molecular mechanisms underlying PPAR -ligand–s...

Most cis-acting regulatory elements have generally been assumed to activate a single nearby gene. However, many genes are clustered together, raising the possibility that they are regulated through a common element. We show here that a single peroxisome proliferator response element (PPRE), located between the mouse PEX11 alpha and perilipin genes, confers on both genes activation by peroxisome...

The transport and metabolism of organic cationic endobiotics, nutrients, and drugs are essential hepatic functions. Slc22A1 is the basolateral liver transporter mediating the uptake of organic cations; however, little is known about the regulation of this transport protein. Peroxisome proliferator agonist receptor (PPAR)-alpha and -gamma agonists are commonly used agents that regulate many hepa...

Purpose: The peroxisome proliferator-activated receptor(PPAR ), a ligand-dependent transcription factor belonging to the family of nuclear receptors, has been implicated in the control of cyclooxygenase (COX) 2 expression in some tissue, although the exact mechanism(s) of this activity has not been elucidated. In this study we explored the possible mechanism(s) of control of COX-2 gene expressi...

High cross-polarization isolation (CPI) is crucial to the accurate polarization measurement using polarimetric phased array radar (PPAR). In this article, we propose an adaptive direction-dependent state configuration ( AD 2 PSC) method improve isolation. Compared with conventional fixed of radi...

Peroxisome proliferator-activated receptors (PPARs) are involved in the regulation of lipid and glucose metabolism. PPAR agonists improve insulin sensitivity and hyperglycemia and are effective in treating type 2 diabetes mellitus (T2DM), whereas PPAR agonists are used to treat dyslipidemia and atherosclerosis. The goal here was to examine the efficacy of a selective PPAR agonist {(S)-3-[3-(1-c...

Journal of Lipid Research Volume 50, 2009 1663 Copyright © 2009 by the American Society for Biochemistry and Molecular Biology, Inc. Peroxisome proliferator-activated receptors (PPAR) are a family of ligand-activated nuclear receptors that induce transcription of multiple genes encoding proteins involved in fatty acid and glucose metabolism, as well as cell differentiation ( 1, 2 ). Because abn...

Activation of the nuclear receptor/transcription factor, peroxisome proliferator-activated receptor (PPAR ), is a newly defined target for limiting vascular pathologies. PPAR is expressed in human and animal models of vascular disease, with particularly high levels being present in the cells of the neointimal microenvironment. In the present study, we show that intimal smooth muscle cells in vi...

Kriska T, Cepura C, Gauthier KM, Campbell WB. Role of macrophage PPAR in experimental hypertension. Am J Physiol Heart Circ Physiol 306: H26–H32, 2014. First published October 25, 2013; doi:10.1152/ajpheart.00287.2013.—Targeted disruption of the Alox15 gene makes mice resistant to angiotensin II-, DOCA/salt-, and N -nitroL-arginine methyl ester (L-NAME)-induced experimental hypertension. Macrop...