Matrix metalloproteinase 8 (MMP8), an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. We identified three single nucleotide polymorphisms (SNPs) at 2799C/T, 2381A/G and 117C/G from the major transcription start site in the MMP8 gene, and determined the functional significance of these SNPs by ana...

BACKGROUND Preterm birth (PTB) is a major cause of infant morbidity and mortality, but the relationship between comorbidity and PTB by clinical subtype and severity of gestational age remains poorly understood. We evaluated associations between maternal comorbidities and PTB by clinical subtype and gestational age. METHODS We conducted a retrospective cohort study of 1,329,737 singleton birth...

BACKGROUND Babies born after midtrimester preterm prelabour rupture of membranes (PPROM) are at risk to develop neonatal pulmonary hypoplasia. Perinatal mortality and morbidity after this complication is high. Oligohydramnios in the midtrimester following PPROM is considered to cause a delay in lung development. Repeated transabdominal amnioinfusion with the objective to alleviate oligohydramni...

OBJECTIVE To review the evidence and provide recommendations on the use of antibiotics in preterm premature rupture of the membranes (PPROM). OUTCOMES Outcomes evaluated include the effect of antibiotic treatment on maternal infection, chorioamnionitis, and neonatal morbidity and mortality. EVIDENCE Published literature was retrieved through searches of Medline, EMBASE, CINAHL, and The Coch...

Background & Aims: Preterm premature rupture of membranes (PPROM) is the leading cause of preterm birth and perinatal mortality and morbidity, and complications. The objective of the present study was to assess the effect of progesterone agents (rectal suppositories and weekly injection of 17- hydroxyprogesterone caproate) on latency period in women with PPROM. Methods: This randomized, double-...

Objective The aim of the present study was to evaluate impact residual anhydramnios following preterm premature rupture membranes (PPROM) on respiratory distress syndrome (RDS) after pregnancy expectantly managed. Methods This retrospectively conducted at Erciyes University Medical School, Turkey. It assessed women with singleton pregnancies admitted hospital between 2010 and 2020 for expectant...

OBJECTIVES This study aimed to evaluate the maternal and fetal outcomes in PROM PRE-PROM at tertiary care hospitals. METHODOLOGY Cross-sectional was carried out department of obstetrics gynaecology Khyber Teaching Hospital Peshawar after ethical approval institutional board. Patients who fulfilled inclusion criteria were selected. On arrival, detailed history taken, physical obstetrical examina...

Background: In neonates, blood flow to the brain as measured by peak systolic velocity (PSV) in middle cerebral artery (MCA) is altered pregnancies affected chorioamnionitis. Objective: We aim determine whether PSV and other measures of MCA fetus are prior development clinical chorioamnionitis following preterm prelabor rupture membranes (PPROM). Methods: This was a prospective observational st...

BACKGROUND We aimed to investigate the treatment efficacy of ampicillin prophylaxis accompanied by Lactobacillus casei rhamnosus over the latency period following preterm premature rupture of membranes (PPROM). METHODS Records of 40 patients who presented with PPROM between 23(0/7)-31(6/7) weeks were analyzed retrospectively. Patients were divided into two groups: group 1 (n=20), treated with...

OBJECTIVE This study was undertaken to study the pharmacokinetics of intravenously administered amoxicillin in pregnant women with preterm premature rupture of the membranes (PPROM). STUDY DESIGN Healthy women with PPROM were recruited and treated with amoxicillin (2 g initially and 1 g subsequently). Blood samples were obtained from the opposite arm and concentrations determined with the use...