Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxa...

In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed var...

Schistosomiasis is a parasitic worm disease that affects more than 200 million people worldwide, and the drug praziquantel remains the only treatment. Recently there have been reports of patients showing signs of resistance to praziquantel. Consequently, there is an urgent need to develop a new drug to serve as an alternative to praziquantel. In this experiment, we will determine potential inhi...

Objectives: Hepatic Schistosomiasis resulted in the morbidity from infection due to its complications of liver fibrosis. However, there are few medicines or means avai lable to contro l and t reat f ibrosis in Schistosomiasis. The aim of this study was to assess the beneficial effects of immunomodulating agents in hepatic schistosomal fibrosis. Methods: Three hundred male Swiss albino mice infe...

A esquistossomose é uma doença negligenciada desencadeada pelo Schistosoma mansoni. O praziquantel (PZQ) o fármaco de primeira escolha no tratamento da esquistossomose, além outras doenças negligenciadas causadas por helmintos. Contudo, a dificuldade adesão ao e uso incorreto desse medicamento têm demonstrado resistência do parasito praziquantel. Para elaboração deste artigo, realizou-se prospe...

Schistosomiasis is one of the oldest and commonest parasitic infestations of mankind and one of the leading infestations of public health concern. Hitherto, praziquantel has been the only drug for mass eradication of Schistosomiasis. Few reports have shown possible resistance of the schistosome to praziquantel in some part of the world with global concern about the future of the drug. We report...

The occurrence of schistosomiasis within African infants and preschool children has been much better documented in recent years, revealing an important burden of disease previously overlooked. Despite mounting evidence showing that treatment with praziquantel is safe, beneficial, and could be delivered within ongoing public health interventions, young children still do not have satisfactory acc...

A 25-year-old male Nigerian undergraduate who had earlier been treated with praziquantel for schistosomal epidydymitis presented with clinical features of pyelonephritis, and radiological appearances of bilateral hydroureteronephrosis with fibrosis of lower ureters. Surgical resection of the ureters, Boari flap and Psoas hitch reconstruction were done. The histology of the resected ureters prov...

Protoscoleces of Echinococcus granulosus were cultured in vitro in 500, 250 or 100 micrograms/l albendazole sulphoxide for 1,3,7,10,14d and then 'rescued' (R) into drug-free medium for the remainder of the culture period. Successful minimum lengths of therapy were much longer than for praziquantel, and only at 500 micrograms/l was the 10dR treatment as effective as continuous therapy for 28d. T...

Background: More than 650 types of leech have been recognized in the world that 50 types of these nutrition of blood mammals. So far in the different Nations Pharmacopeia  not registered drug  for treatment of complications with leech in the world .Chamomile is one of the most widely used and well-documented medicinal plants in the world which used for treatment of anti -spasmodic ,anti-inflamm...