The relationship between smoking, lung cancer and airflow obstruction is recognised but it is unclear whether the presence of minimal lung function damage constitutes an independent risk factor for the development of lung cancer. In order to identify those individuals at higher risk of lung cancer on the basis of functional impairment, we evaluated baseline pulmonary function tests of 3,806 hea...

Research and development of multi-target inhibitors has attracted increasing attention as anticancer therapeutics. B-RafV600E synergistically works with vascular endothelial growth factor receptor 2 (KDR) to promote the occurrence and progression of cancers, and the development of dual-target drugs simultaneously against these two kinds of kinase may offer a better treatment advantage. In this ...

This work presents a simple artificial neural network which classifies, from their sequences alone, proteins into classes: the membrane protein class and the non-membrane protein class. This is important in the functional assignment and analysis of Open Reading Frames (ORF) identified in complete genomes and, especially those ORF’s that correspond to proteins with unknown function. The network ...

PrEd [Ber00] is a force-directed algorithm that improves the existing layout of a graph while preserving its edge crossing properties. The algorithm has a number of applications including: improving the layouts of planar graph drawing algorithms, interacting with a graph layout, and drawing Euler-like diagrams. The algorithm ensures that nodes do not cross edges during its execution. However, P...

PRED(BALB/c) is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2(d)) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2(d) class I (H2-K(d), H2-L(d) and H2-D(d)) and class II (I-E(d) and I-A(d)) molecules. The prediction system utilizes quantitative matrices, which were rigorously validat...

PRED is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2 class I (H2-K, H2-L and H2-D) and class II (I-E and I-A) molecules. The prediction system utilizes quantitative matrices, which were rigorously validated using experimentally deter...

OBJECTIVE We aimed to perform an observational study of age at loss of independent ambulation (LoA) and side-effect profiles associated with different glucocorticoid corticosteroid (GC) regimens in Duchenne muscular dystrophy (DMD). METHODS We studied 340 participants in the Cooperative International Neuromuscular Research Group Duchenne Natural History Study (CINRG-DNHS). LoA was defined as ...

STUDY OBJECTIVE To determine the additive effect of oral theophylline in patients with stable COPD who received both inhaled salbutamol, 400 micrograms, and ipratropium bromide, 80 micrograms, four times daily administered with a metered-dose inhaler. DESIGN Twenty-four male patients with stable COPD (FEV1, 0.96 +/- 0.43 L; 36.8 +/- 17.0 percent predicted [% pred]) completed a randomized, dou...

To cite: Davidsen JR, Nygaard L, Laursen CB, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016216542 DESCRIPTION A 67-year-old never-smoking man with a wellknown congenital diaphragmatic hernia, verified on a 3-year-old chest X-ray (figure 1), consulted his general practitioner due to the detection of intermittent blood stool for 2 months, but emphasised...

The present study aims to derive guidelines that identify patients for whom spirometry can reliably predict a reduced total lung capacity (TLC). A total of 12,693 lung function tests were analysed on Caucasian subjects, aged 18-70 yrs. Restriction was defined as a reduced TLC. Lower limits of normal (LLN) for TLC were obtained from the European Respiratory Society recommended reference equation...