نتایج جستجو برای: predictive biomarker
تعداد نتایج: 196512 فیلتر نتایج به سال:
Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Experimental Design:We use a NAMPT inhibitor, GNE-617, to evaluate nicotinic acid rescue status in a panel ofmore than 400 cancer cell lines.Using correlative analysis andRNA interference (RNAi), we identify a specific biomarker for nicotinic acid rescue status. We next det...
Recent development of high-throughput technology has accelerated interest in the development of molecular biomarker classifiers for safety assessment, disease diagnostics and prognostics, and prediction of response for patient assignment. This article reviews and evaluates some important aspects and key issues in the development of biomarker classifiers. Development of a biomarker classifier fo...
Abstract Purpose Advances in the pathophysiological characterization of psychosis has led to a newfound role biomarkers diagnostic and prognostic contexts. Further, advances accuracy sensitivity nuclear medicine imaging techniques, specifically positron emission tomography (PET), have improved ability diagnose manage individuals experiencing first-episode or those at greater risk for developing...
The recent successes in the use of immunotherapy to treat cancer have led to a multiplicity of new compounds in development. Novel clinical-grade biomarkers are needed to guide the choice of these agents to obtain the maximal likelihood of patient benefit. Predictive biomarkers for immunotherapy differ from the traditional biomarkers used for targeted therapies: the complexity of the immune res...
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