A computational investigation of high-pressure hydrogen–air partially premixed flames (PPFs) is reported to characterize the effect of pressure on the flame structure, and the relevance of reaction limits for these flames. The flames are computed using the Mueller mechanism consisting of 19 elementary reactions and 9 species. Although the mechanism has been validated during previous investigati...

INTRODUCTION Increasing emphasis is being placed on insulin use among patients with type 2 diabetes mellitus (T2DM). Basal-bolus (BB) therapy is regarded as the gold standard, but a high frequency of injections and the general complexity of this therapy are seen as barriers in real-world practice. Here we describe the characteristics and treatment patterns of patients with T2DM receiving BB in ...

One of the well-known properties of turbulent, premixed flames is that their speed of propagtion is correlated to the intensity of the turbulence they encounter. A simple consequence is that these types of flames are inherently unstable. Given a source of turbulence, if the flame is propagating faster than the mean flow, it will drift upstream and encounter increased turbulent intensities that ...

Detailed studies of flame-vortex interactions are extremely valuable to improve our understanding of turbulent combustion regimes. Combined experimental and numerical studies have already been performed in the premixed case during previous investigations. Therefore, we decided to carry out a detailed experimental investigation on the regimes observed during interaction of a vortex ring and a no...

In the present study, we have formulated the G equation concept for large-eddy simulation (LES) of premixed turbulent combustion. The developed model for the subgrid burning velocity is shown to correctly reflect Damköhler’s limits for largeand small-scale turbulence. From the discussion of the regime diagram for turbulent premixed combustion, it is shown that given a particular configuration o...

The speed of propagation of a premixed turbulent flame correlates with the intensity of the turbulence encountered by the flame. One consequence of this property is that premixed flames in both laboratory experiments and practical combustors require some type of stabilization mechanism to prevent blow-off and flashback. The stabilization devices often introduce a level of geometric complexity t...

This review addresses the apparent disconnect between international guideline recommendations, real-life clinical practice and the results of clinical trials, with regard to the initiation of insulin using basal (long-acting) or premixed insulin analogues in patients with type 2 diabetes (T2D). English language guidelines vary considerably with respect to recommended glycaemic targets, the sele...

The Conditional Moment Closure (CMC) model provides a means of closing the subgrid terms for the reaction rates through the assumption that departures of the mean filtered reaction rate (conditional on a mixture fraction or progress variable) are small. Turbulentchemistry interaction is incorporated through a conditional scalar dissipation. To date, all Large Eddy Simulation implementations of ...