The Rai and Van Ryzin dose-response model proposed for teratology experiments has been characterized for its appropriateness and applicability in modeling the dichotomous response data from developmental toxicity studies. Modifications were made in the initial probability statements to reflect more accurately biological events underlying developmental toxicity. Data sets used for the evaluation...

down syndrome (ds) is a birth defect with huge medical and social costs, caused by trisomy of whole or part of chromosome 21. it is the most prevalent genetic disease worldwide and the common genetic cause of intellectual disabilities appearing in about 1 in 400-1500 newborns. although the syndrome had been described thousands of years before, it was named after john langdon down who described ...

Objetivo: Analizar los controles prenatales insuficientes en adolescentes primigestas. Método: Descriptiva observacional. Resultados: El 25% de primigestas dicen conocer os riesgos que se pueden presentar por no asistir al Control Prenatal es la presencia traumatismos nacer él bebé. Conclusión: Concientizar a las mediante asistencia del control prenatal, reduciendo así complicaciones ponen ries...

Organophosphate flame retardants (OPFRs) are substantially applied as and plasticizers in consumer products. Although the embryonic developmental toxicity of OPFRs has been reported, human data limited critical windows susceptibility to exposure urgently need be identified. Here, we investigated trimester-specific associations between prenatal OPFR birth size for first time. The concentrations ...

Epidemiological investigations have shown that fetuses with intrauterine growth retardation (IUGR) are susceptible to adult metabolic syndrome. Clinical investigations and experiments have demonstrated that caffeine is a definite inducer of IUGR, as children who ingest caffeine-containing food or drinks are highly susceptible to adult obesity and hypertension. Our goals for this study were to i...