Combretastatin A-4 (CA-4) is a naturally occurring microtubular-destabilising agent that possesses potent anti-tumour and anti-vascular properties both in vitro and in vivo. Clinical trials to date indicate that its water-soluble prodrug, combretastatin A-4 phosphate (CA-4P), is well tolerated at therapeutically useful doses. However, the stilbenoid structure of CA-4, consisting of two phenyl r...

BACKGROUND Derivatives of D-glucosamine and D-galactosamine represent an important family of the cell surface glycan components and their fluorinated analogs found use as metabolic inhibitors of complex glycan biosynthesis, or as probes for the study of protein-carbohydrate interactions. This work is focused on the synthesis of acetylated 3-deoxy-3-fluoro, 4-deoxy-4-fluoro and 3,4-dideoxy-3,4-d...

In the title compound, C(10)H(7)ClN(4), the quinoline ring system is planar [maximum deviation 0.0035 (10) Å]. The crystal structure is stabilized by van der Waals and π-π stacking inter-actions [centroid-centroid distance 3.6456 (17) Å].

In the mol-ecule of the title compound, C(9)H(9)N(3)O, the angle formed by the least-squares line through the azide group with the normal to the plane of the benzene plane ring is 46.62 (16)°. The crystal structure features C-H⋯O hydrogen bonds, which link the mol-ecules into zigzag chains running parallel to [010].

The reaction of 4-amino-5-benzylamino-3-(4-chlorophenyl)-1H-pyrazole (1) with substituted diarylidenketones (2) constitutes a convenient synthetic route to the hitherto unknown 1-benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines (3). Structures of all products were consistent with their IR, H-NMR, C-NMR and MS spectral data. X-ray crystallography ...

epoxyalcohols are useful intermediates in complex organic synthesis, and recently they have been recognized as versatile intermediates for synthesis of natural products. the treatments of cis and trans 2-(1-cyclohexenyl) cyclohexanol, separately with paranirto perbenzoic acid gave the corresponding 2-(1- cyclohexenyl) cyclohexanol oxide. on the other hand, 2-cyclohexylidene cyclohexanol oxide w...