This paper reports the occurrence of retinal detachment in 18 patients suffering from congenital glaucoma. Difficulty in establishing control of the glaucoma and the presence of high myopia were common findings. The poor results of detachment surgery were related to opacites in the media preventing evaluation of the renal details and the development of massive preretinal retraction.

PURPOSE Ephrin ligands and their Eph receptors are key regulators of endothelial cell (EC) proliferation, migration, adhesion, and repulsion during mammalian vascular development. The hypothesis was that these molecules also play a role in pathologic neovascularization (NV) in the mouse model of oxygen-induced retinopathy. METHODS C57BL/6 mice at postnatal day (P)7 were exposed to 75% oxygen ...

Retinopathy of prematurity (ROP) is a potentially blinding retinal disease that affects prematurely born infants. ROP is characterized by abnormal blood vessel growth in the retina. In order to investigate a treatment for this condition, the mechanisms behind blood vessel growth involving ephrinB2 reverse signaling in pathological retinal neovascularization must be understood. Litters of transg...

AIM To determine the spatial and temporal changes in the staining pattern of the VEGF receptors FLT-1, KDR, and the putative receptor FLT-4 during the pathogenesis of diabetic retinopathy. METHODS Immunohistochemical localisation of VEGF receptors, using antibodies against FLT-1, FLT-4, and KDR, was carried out on specimens of normal human retina (n = 10), diabetic retinas (a) with no overt r...