BACKGROUND AND AIMS Hepatic fibrosis is associated with elevated sinusoidal pressure, which can be transmitted to the hepatic stellate cells (HSCs) in the perisinusoidal space of Disse. Here, we sought to determine the effects of pressure on cellular growth and Src-dependent signaling pathways in the rat HSCs. METHODS Cultured rat HSCs were exposed to pressures (0 to 80 mmHg) by using a press...

Both insulin resistance and insulin concentrations correlate with blood pressure in nondiabetic subjects, but there is no consensus on these relations in subjects with non-insulin-dependent diabetes, perhaps because of the use of nonspecific insulin assays and clinic blood pressure measurement. Therefore, we have investigated the relation between ambulatory blood pressure, insulin sensitivity (...

The present study examined the level of generation of reactive oxygen species (ROS) and roles of inactivation of the phosphatase PTEN and the PI3K/Akt signaling pathway in response to an increase in intramural pressure-induced myogenic cerebral arterial constriction. Step increases in intraluminal pressure of cannulated cerebral arteries induced myogenic constriction and concomitant formation o...

the “driving force - pressure - state - impact – response” modeling framework isadopted to consider the formation mechanisms of environmental risks and the requirements ofecological environment protection. moreover, a systematical index system and evaluation model forthe measurement of the coastal ecological security level is put forward in this paper to assess thestate of coastal ecological en...

System designs, optimizing resource allocation to organization units, is still being considered as a complicated problem especially when there are multiple inputs and outputs related to a unit. The algorithm presented here will divide the frontiers obtained with DEA. In this way, we investigate a new approach for resource allocation.

This study is limited to study of buckling analysis of a sandwich cylindrical shell with functionally graded face sheets and homogenous core. High-order sandwich plate theory is improved by considering the in-plane stresses of the core that usually are ignored in the analysis of sandwich structures. Assume that all properties of the face sheets and the core are temperature dependent. Strain com...

This paper contains a strain gradient theory to capture size effects in rotating nanodisks of variable thickness under thermal and mechanical loading. Material properties of nanodisks have been taken homogeneous material. The strain gradient theory and the Hamilton’s principle are employed to derive the governing equations. Due to complexity of the governing differential equation and boundary c...